Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 215157..216592 Replicon chromosome
Accession NC_021025
Organism Mycoplasma mycoides subsp. mycoides SC str. Gladysdale

Toxin (Protein)


Gene name abiEii Uniprot ID Q6MU66
Locus tag MMS_RS00970 Protein ID WP_011166377.1
Coordinates 215157..215996 (-) Length 280 a.a.

Antitoxin (Protein)


Gene name abiEi Uniprot ID A0A7U5HSJ1
Locus tag MMS_RS00975 Protein ID WP_015545367.1
Coordinates 215996..216592 (-) Length 199 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMS_RS06745 211758..211922 + 165 WP_015545676.1 hypothetical protein -
MMS_RS00955 212035..213636 + 1602 WP_162465392.1 IS1634 family transposase -
MMS_RS06805 213702..215116 + 1415 WP_162465382.1 IS3 family transposase -
MMS_RS00970 215157..215996 - 840 WP_011166377.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MMS_RS00975 215996..216592 - 597 WP_015545367.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
MMS_RS00980 216802..218106 - 1305 WP_011166379.1 DUF285 domain-containing protein -
MMS_RS00985 218212..220902 - 2691 WP_011166380.1 alanine--tRNA ligase -
MMS_RS00990 220974..221468 - 495 WP_011166381.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-53)


Sequences

Toxin        


Download         Length: 280 a.a.        Molecular weight: 33073.99 Da        Isoelectric Point: 9.7009

>T29336 WP_011166377.1 NC_021025:c215996-215157 [Mycoplasma mycoides subsp. mycoides SC str. Gladysdale]
MNLQKLKSICKRLSSETKTNYNIILKHYFMISILEKIVKSKNKQNFVIKGGFLLSNMMSLNERTTQDIDCLIKGINFVKE
NILRTISDVLRYDFTDFIKYEIKEITEIKKRDKYNGFRVKILCKLEKLEEIVKIDLAIGDVVTPSEIKYNFRNIFSNSSF
EIQAYNLETILAEKIFIINNLNIQSTRIKDLYDIFLIYSFKEFEIDYNILKCACLNTFKKRNTVFNIDLVLSLLNEINQL
DIFELLNNYRQKYFYAQKIEFKILIKSVIKFLEKLKNI

Download         Length: 840 bp

>T29336 NC_021025:c215996-215157 [Mycoplasma mycoides subsp. mycoides SC str. Gladysdale]
ATGAACTTACAGAAATTAAAATCAATTTGTAAAAGGTTATCAAGTGAAACAAAAACAAATTATAATATCATCTTAAAACA
TTACTTTATGATATCCATATTAGAAAAAATTGTTAAAAGTAAAAATAAACAAAACTTTGTAATTAAAGGTGGGTTCTTAC
TTTCTAATATGATGAGTTTAAACGAAAGAACCACTCAAGATATAGATTGCTTAATAAAAGGTATCAATTTTGTTAAAGAG
AATATTCTAAGAACTATTTCTGATGTATTAAGATATGATTTTACTGACTTTATAAAATATGAAATAAAAGAAATAACAGA
AATAAAAAAGAGAGACAAATATAATGGATTTAGAGTCAAAATATTATGCAAATTAGAAAAGTTGGAAGAAATAGTAAAAA
TAGATTTAGCAATTGGTGATGTTGTAACACCGTCTGAGATTAAATACAATTTTAGAAATATCTTTTCAAATAGTAGCTTT
GAAATACAAGCATATAATCTAGAAACAATATTAGCTGAAAAAATATTTATAATTAATAATTTAAATATACAATCAACTAG
AATAAAAGATCTTTATGATATTTTTTTAATATATAGCTTTAAAGAGTTTGAGATTGATTATAATATTCTAAAATGTGCTT
GTTTAAATACTTTTAAAAAAAGAAATACTGTTTTTAATATAGATTTAGTACTTAGTTTATTAAATGAAATTAACCAATTA
GATATTTTTGAATTACTTTGAAATAATTACAGGCAAAAATACTTTTACGCCCAAAAAATAGAATTTAAAATACTGATAAA
ATCTGTAATTAAGTTTTTAGAAAAGTTAAAAAATATTTAA

Antitoxin


Download         Length: 199 a.a.        Molecular weight: 23637.30 Da        Isoelectric Point: 9.3217

>AT29336 WP_015545367.1 NC_021025:c216592-215996 [Mycoplasma mycoides subsp. mycoides SC str. Gladysdale]
MNYKEQLIKEAKKRAGIITRKEIMNLKIPSIYITRMIRSNELEKVDIGIYALTSENWYYDPDYNFSIRHKTPIFSYTYAL
TFFDFTDVIPMFRDVTVYHGYNAHNLDPQTRVHYVSKDIYELGVVEVKTNCGNKIRAYDIERTICDFIKHRDKIEAELFA
KTMYKYSEYEKRDKKLHEYAKKMNIGKKVYEVFQVLV

Download         Length: 597 bp

>AT29336 NC_021025:c216592-215996 [Mycoplasma mycoides subsp. mycoides SC str. Gladysdale]
ATGAATTATAAAGAACAGCTGATAAAAGAAGCTAAAAAAAGAGCCGGTATTATTACAAGAAAAGAAATTATGAATTTAAA
AATTCCATCAATTTATATTACAAGAATGATTAGAAGTAATGAATTAGAAAAAGTCGATATTGGTATTTATGCTCTAACTT
CTGAAAATTGGTACTATGATCCTGATTATAATTTTAGTATCAGACATAAAACACCTATTTTTTCTTATACTTATGCACTT
ACATTTTTTGATTTTACAGATGTTATTCCAATGTTTCGTGATGTAACTGTTTATCATGGATATAATGCTCATAATTTAGA
CCCACAAACTAGAGTACACTATGTTTCAAAAGATATATATGAACTTGGAGTTGTAGAAGTAAAAACAAATTGTGGTAATA
AAATTAGAGCTTATGATATTGAAAGAACAATTTGTGATTTTATTAAGCATAGAGATAAAATCGAAGCTGAACTATTTGCA
AAAACTATGTATAAATATTCTGAATATGAAAAAAGAGATTGAAAAAAACTTCATGAATATGCTAAAAAAATGAACATTGG
TAAGAAAGTTTATGAAGTTTTTCAAGTATTAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q6MU66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U5HSJ1

References