293351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2773419..2774086 Replicon chromosome
Accession NZ_LT615377
Organism Escherichia coli isolate 106

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag BV315_RS14785 Protein ID WP_001094400.1
Coordinates 2773757..2774086 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag BV315_RS14780 Protein ID WP_000072690.1
Coordinates 2773419..2773736 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV315_RS14750 2768471..2769480 - 1010 Protein_2648 arsenic transporter -
BV315_RS14755 2769622..2771325 + 1704 WP_001698958.1 hypothetical protein -
BV315_RS14760 2771897..2772120 + 224 Protein_2650 DUF905 family protein -
BV315_RS14765 2772223..2772681 + 459 WP_000211841.1 antirestriction protein -
BV315_RS14770 2772690..2773172 + 483 WP_001407480.1 RadC family protein -
BV315_RS14775 2773181..2773381 + 201 WP_001395452.1 DUF987 domain-containing protein -
BV315_RS14780 2773419..2773736 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BV315_RS14785 2773757..2774086 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
BV315_RS14790 2774450..2779030 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T293351 WP_001094400.1 NZ_LT615377:2773757-2774086 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT293351 WP_000072690.1 NZ_LT615377:2773419-2773736 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References