Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 887208..887839 Replicon chromosome
Accession NZ_LT615228
Organism Polynucleobacter necessarius isolate PPGSP1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DXE33_RS04600 Protein ID WP_114638852.1
Coordinates 887208..887606 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DXE33_RS04605 Protein ID WP_068323602.1
Coordinates 887606..887839 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE33_RS04585 883122..883805 - 684 WP_114638846.1 outer membrane lipoprotein carrier protein LolA -
DXE33_RS04590 883815..886127 - 2313 WP_114638848.1 DNA translocase FtsK -
DXE33_RS04595 886167..887123 + 957 WP_114638850.1 thioredoxin-disulfide reductase -
DXE33_RS04600 887208..887606 - 399 WP_114638852.1 type II toxin-antitoxin system VapC family toxin Toxin
DXE33_RS04605 887606..887839 - 234 WP_068323602.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DXE33_RS04610 888194..890254 - 2061 Protein_913 sodium-translocating pyrophosphatase -
DXE33_RS04615 890439..890975 + 537 WP_114638854.1 inorganic diphosphatase -
DXE33_RS04620 891004..892623 + 1620 WP_114638856.1 NAD+ synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14999.35 Da        Isoelectric Point: 7.4626

>T293320 WP_114638852.1 NZ_LT615228:c887606-887208 [Polynucleobacter necessarius]
MLKYLLDTNIVIYVMKRKPLEVLKVFNKNANRMAISTITLAELMYGAEKSQQVESNLNNIEDFVSHLEVLPYDIYATQHY
GQIKAFLESTGKPIGVNDIHIAAHARSHGLTLVTNNLSEFKRVPNLALENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8952.09 Da        Isoelectric Point: 6.3219

>AT293320 WP_068323602.1 NZ_LT615228:c887839-887606 [Polynucleobacter necessarius]
MAISTVFTNNRTQAVRLPAEMRLPENVRKVNVRAKGRERIIAPIENMWDNYFLGDARVSDDFMNERGSQEQSDREPL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References