Detailed information of TA system TA029332

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 1251907..1252448
• Replicon: draft genome
• Accession: NC_021015
• Organism: Ruminococcus torques L2-14

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: RTO_RS05830
• Protein ID: WP_015528462.1
• Coordinates: 1252173..1252448 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: RTO_RS05825
• Protein ID: WP_015528461.1
• Coordinates: 1251907..1252176 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RTO_RS05810	1246943..1248010	+	1068	Protein_1155	helicase	-
RTO_RS05815 (RTO_12150)	1248092..1250848	+	2757	WP_015528460.1	YodL domain-containing protein	-
RTO_RS05820	1251402..1251560	+	159	WP_155203109.1	hypothetical protein	-
RTO_RS05825 (RTO_12170)	1251907..1252176	+	270	WP_015528461.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
RTO_RS05830 (RTO_12180)	1252173..1252448	+	276	WP_015528462.1	type II toxin-antitoxin system YafQ family toxin	Toxin
RTO_RS05840 (RTO_12190)	1254646..1255164	-	519	WP_015528463.1	nitroreductase family protein	-
RTO_RS05845 (RTO_12200)	1255384..1255716	+	333	WP_015528464.1	helix-turn-helix domain-containing protein	-
RTO_RS05850 (RTO_12210)	1256054..1256398	+	345	WP_015528465.1	cupin domain-containing protein	-
RTO_RS15550	1256409..1256966	+	558	Protein_1163	sugar O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-86)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10798.39 Da
• Isoelectric Point: 8.4636

>T29332 WP_015528462.1 NC_021015:1252173-1252448 [[Ruminococcus] torques L2-14]
MKYTVKPTSKFQNDLKRIQKRGYDMRLMTDVIKKLANGEILPPKNRDHNLSGNYSNCRECHIAPDWLLIYEVYEDELFLY
LTRTGSHSDLF

Nucleotide

• Length: 276 bp

>T29332 NC_021015:1252173-1252448 [[Ruminococcus] torques L2-14]
ATGAAATATACGGTTAAGCCGACCAGTAAGTTTCAAAATGACTTAAAACGTATTCAGAAACGTGGATACGATATGAGATT
AATGACTGATGTCATCAAAAAATTGGCAAATGGTGAAATATTACCGCCGAAGAATCGAGATCATAATCTTTCAGGAAATT
ATAGTAATTGCAGAGAATGTCATATTGCTCCTGATTGGTTGTTGATTTATGAAGTCTATGAAGATGAACTATTCTTATAT
TTAACAAGGACAGGAAGTCATAGCGACTTATTTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10068.47 Da
• Isoelectric Point: 4.2958

>AT29332 WP_015528461.1 NC_021015:1251907-1252176 [[Ruminococcus] torques L2-14]
MANVSIRMDDNLKKQAEDLFNDLGMNLTTAFTIFVKQAIREQGIPFEVTRETPNSETISAINEVQQMKQNPSLGKAYTDV
DKMMEELLA

Nucleotide

• Length: 270 bp

>AT29332 NC_021015:1251907-1252176 [[Ruminococcus] torques L2-14]
ATGGCAAATGTATCAATTAGAATGGATGATAATTTAAAGAAACAAGCAGAAGATCTTTTCAATGATTTAGGTATGAATCT
GACAACTGCATTCACAATTTTTGTAAAACAGGCAATCAGAGAACAGGGAATACCATTTGAGGTTACCAGAGAAACACCTA
ATAGTGAAACAATATCAGCAATTAATGAAGTACAGCAAATGAAACAGAATCCTTCTCTTGGAAAAGCATATACAGATGTG
GACAAGATGATGGAGGAATTATTAGCATGA