Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2476912..2477435 Replicon chromosome
Accession NZ_LT615218
Organism Staphylococcus aureus strain AUS0325

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BQ3358_RS12660 Protein ID WP_069992042.1
Coordinates 2476912..2477178 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag BQ3358_RS12665 Protein ID WP_000587616.1
Coordinates 2477178..2477435 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ3358_RS12640 2472219..2473406 - 1188 WP_000026189.1 MFS transporter -
BQ3358_RS12645 2473802..2474578 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
BQ3358_RS12650 2474571..2475233 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
BQ3358_RS12655 2475481..2476557 - 1077 WP_064127132.1 M42 family metallopeptidase -
BQ3358_RS12660 2476912..2477178 - 267 WP_069992042.1 Txe/YoeB family addiction module toxin Toxin
BQ3358_RS12665 2477178..2477435 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BQ3358_RS12675 2477794..2478249 + 456 WP_000732076.1 DUF1307 domain-containing protein -
BQ3358_RS12680 2478417..2479994 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
BQ3358_RS12685 2480189..2480938 + 750 WP_000072458.1 hypothetical protein -
BQ3358_RS12690 2481162..2482355 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10690.27 Da        Isoelectric Point: 10.1597

>T293318 WP_069992042.1 NZ_LT615218:c2477178-2476912 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIIETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT293318 WP_000587616.1 NZ_LT615218:c2477435-2477178 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References