Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2107293..2107807 Replicon chromosome
Accession NZ_LT615218
Organism Staphylococcus aureus strain AUS0325

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag BQ3358_RS10710 Protein ID WP_000581792.1
Coordinates 2107293..2107502 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag BQ3358_RS10715 Protein ID WP_000138932.1
Coordinates 2107514..2107807 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ3358_RS10690 2102801..2104159 - 1359 WP_000611459.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
BQ3358_RS10695 2104174..2105244 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
BQ3358_RS10700 2105562..2106764 + 1203 WP_001109936.1 rod shape-determining protein RodA -
BQ3358_RS10705 2107028..2107165 - 138 WP_000828354.1 hypothetical protein -
BQ3358_RS10710 2107293..2107502 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
BQ3358_RS10715 2107514..2107807 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
BQ3358_RS10720 2107973..2109457 + 1485 WP_000571549.1 cardiolipin synthase -
BQ3358_RS10725 2109485..2110132 + 648 WP_001187630.1 HD domain-containing protein -
BQ3358_RS10730 2110598..2111470 - 873 WP_000725802.1 membrane protein insertase YidC -
BQ3358_RS10735 2111556..2112197 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T293314 WP_000581792.1 NZ_LT615218:c2107502-2107293 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT293314 WP_000138932.1 NZ_LT615218:c2107807-2107514 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References