Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2087538..2088067 Replicon chromosome
Accession NZ_LT615218
Organism Staphylococcus aureus strain AUS0325

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BQ3358_RS10620 Protein ID WP_000621177.1
Coordinates 2087538..2087900 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag BQ3358_RS10625 Protein ID WP_000948331.1
Coordinates 2087897..2088067 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ3358_RS10595 2084516..2085286 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
BQ3358_RS10600 2085261..2085740 - 480 WP_001190829.1 anti-sigma B factor RsbW -
BQ3358_RS10605 2085742..2086068 - 327 WP_001052491.1 anti-sigma factor antagonist -
BQ3358_RS10610 2086187..2087188 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
BQ3358_RS10620 2087538..2087900 - 363 WP_000621177.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BQ3358_RS10625 2087897..2088067 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
BQ3358_RS10630 2088152..2089300 - 1149 WP_001281147.1 alanine racemase -
BQ3358_RS10635 2089366..2089725 - 360 WP_000581202.1 holo-ACP synthase -
BQ3358_RS10640 2089729..2090220 - 492 WP_001205910.1 PH domain-containing protein -
BQ3358_RS10645 2090207..2091789 - 1583 Protein_2011 PH domain-containing protein -
BQ3358_RS10650 2091782..2092261 - 480 WP_001287078.1 hypothetical protein -
BQ3358_RS10655 2092470..2093030 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13471.72 Da        Isoelectric Point: 10.1654

>T293313 WP_000621177.1 NZ_LT615218:c2087900-2087538 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNTVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT293313 WP_000948331.1 NZ_LT615218:c2088067-2087897 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References