Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/- |
| Location | 1215432..1215997 | Replicon | draft genome |
| Accession | NC_021015 | ||
| Organism | Ruminococcus torques L2-14 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | C7H6P5 |
| Locus tag | RTO_RS05700 | Protein ID | WP_002596328.1 |
| Coordinates | 1215432..1215722 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | C7H6P4 |
| Locus tag | RTO_RS05705 | Protein ID | WP_005924829.1 |
| Coordinates | 1215719..1215997 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RTO_RS05670 | 1210760..1211491 | + | 732 | WP_173012942.1 | ABC transporter permease | - |
| RTO_RS05675 (RTO_11860) | 1211961..1212374 | + | 414 | WP_015524243.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
| RTO_RS05680 (RTO_11870) | 1212478..1212930 | + | 453 | WP_015524244.1 | hypothetical protein | - |
| RTO_RS05685 (RTO_11880) | 1212941..1213402 | + | 462 | WP_015528452.1 | sigma-70 family RNA polymerase sigma factor | - |
| RTO_RS05690 (RTO_11890) | 1213431..1213721 | + | 291 | WP_015524246.1 | DUF3847 domain-containing protein | - |
| RTO_RS05695 (RTO_11900) | 1213909..1215354 | + | 1446 | WP_082424716.1 | MobQ family relaxase | - |
| RTO_RS05700 (RTO_11910) | 1215432..1215722 | - | 291 | WP_002596328.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| RTO_RS05705 (RTO_11920) | 1215719..1215997 | - | 279 | WP_005924829.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| RTO_RS05710 (RTO_11930) | 1216124..1216522 | + | 399 | WP_015528454.1 | cysteine-rich VLP domain-containing protein | - |
| RTO_RS05715 (RTO_11940) | 1216636..1217370 | + | 735 | WP_015528455.1 | phage replisome organizer N-terminal domain-containing protein | - |
| RTO_RS05720 (RTO_11950) | 1217367..1218230 | + | 864 | WP_015528456.1 | ATP-binding protein | - |
| RTO_RS05725 (RTO_11960) | 1218274..1218468 | + | 195 | WP_002596333.1 | transposon-encoded TnpW family protein | - |
| RTO_RS05730 (RTO_11970) | 1218546..1218911 | + | 366 | WP_015528457.1 | hypothetical protein | - |
| RTO_RS05735 | 1219067..1219399 | + | 333 | WP_243441229.1 | type IV secretory system conjugative DNA transfer family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1131582..1237788 | 106206 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11112.87 Da Isoelectric Point: 8.0630
>T29331 WP_002596328.1 NC_021015:c1215722-1215432 [[Ruminococcus] torques L2-14]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK
Download Length: 291 bp
>T29331 NC_021015:c1215722-1215432 [[Ruminococcus] torques L2-14]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAGGACTACAAACGAGCTATAAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCACATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAAGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAGGACTACAAACGAGCTATAAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCACATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAAGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10247.66 Da Isoelectric Point: 4.4692
>AT29331 WP_005924829.1 NC_021015:c1215997-1215719 [[Ruminococcus] torques L2-14]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR
Download Length: 279 bp
>AT29331 NC_021015:c1215997-1215719 [[Ruminococcus] torques L2-14]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCACAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCACAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M4XBM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M4XB19 |