Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1890665..1891441 Replicon chromosome
Accession NZ_LT615218
Organism Staphylococcus aureus strain AUS0325

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag BQ3358_RS09380 Protein ID WP_000031108.1
Coordinates 1890665..1890817 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag BQ3358_RS09385 Protein ID WP_001251224.1
Coordinates 1890842..1891441 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ3358_RS09365 1886857..1887678 + 822 WP_000669376.1 RluA family pseudouridine synthase -
BQ3358_RS09370 1888141..1889526 - 1386 WP_000116234.1 class II fumarate hydratase -
BQ3358_RS09375 1889722..1890117 - 396 WP_000901023.1 hypothetical protein -
BQ3358_RS09380 1890665..1890817 - 153 WP_000031108.1 hypothetical protein Toxin
BQ3358_RS09385 1890842..1891441 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
BQ3358_RS09390 1891600..1892070 - 471 WP_000181392.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
BQ3358_RS09395 1892075..1893202 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
BQ3358_RS09400 1893353..1894075 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
BQ3358_RS09405 1894068..1895525 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T293308 WP_000031108.1 NZ_LT615218:c1890817-1890665 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT293308 WP_001251224.1 NZ_LT615218:c1891441-1890842 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References