Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4535697..4536955 Replicon chromosome
Accession NZ_LT608330
Organism Pseudomonas aeruginosa isolate PA14Or_reads

Toxin (Protein)


Gene name - Uniprot ID A0A0H2Z7F3
Locus tag PHAGEPCYII10_RS20745 Protein ID WP_003140635.1
Coordinates 4535697..4536452 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PHAGEPCYII10_RS20750 Protein ID WP_003086329.1
Coordinates 4536587..4536955 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHAGEPCYII10_RS20735 4530868..4533411 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
PHAGEPCYII10_RS20740 4533566..4534927 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PHAGEPCYII10_RS20745 4535697..4536452 - 756 WP_003140635.1 RES family NAD+ phosphorylase Toxin
PHAGEPCYII10_RS20750 4536587..4536955 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PHAGEPCYII10_RS20755 4537028..4538314 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PHAGEPCYII10_RS20760 4538370..4539959 - 1590 WP_003140637.1 aldehyde dehydrogenase family protein -
PHAGEPCYII10_RS20765 4540038..4540514 + 477 WP_003140638.1 hypothetical protein -
PHAGEPCYII10_RS31350 4540517..4540792 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28220.34 Da        Isoelectric Point: 7.7294

>T293304 WP_003140635.1 NZ_LT608330:c4536452-4535697 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT293304 WP_003086329.1 NZ_LT608330:c4536955-4536587 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z7F3

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References