293303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3585786..3587006 Replicon chromosome
Accession NZ_LT608330
Organism Pseudomonas aeruginosa isolate PA14Or_reads

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PHAGEPCYII10_RS16315 Protein ID WP_003110488.1
Coordinates 3586428..3587006 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PHAGEPCYII10_RS16310 Protein ID WP_003088112.1
Coordinates 3585786..3586340 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHAGEPCYII10_RS16285 3581354..3581905 + 552 WP_003139878.1 XRE family transcriptional regulator -
PHAGEPCYII10_RS16290 3581902..3582300 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PHAGEPCYII10_RS16295 3582313..3582636 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PHAGEPCYII10_RS16300 3582967..3583428 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PHAGEPCYII10_RS16305 3583433..3585628 + 2196 WP_003139882.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PHAGEPCYII10_RS16310 3585786..3586340 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
PHAGEPCYII10_RS16315 3586428..3587006 + 579 WP_003110488.1 HD domain-containing protein Toxin
PHAGEPCYII10_RS16320 3587115..3588302 - 1188 WP_003139884.1 HlyD family efflux transporter periplasmic adaptor subunit -
PHAGEPCYII10_RS16325 3588292..3590463 - 2172 WP_003139887.1 type I secretion system permease/ATPase -
PHAGEPCYII10_RS16330 3590453..3591730 - 1278 WP_003139889.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T293303 WP_003110488.1 NZ_LT608330:3586428-3587006 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT293303 WP_003088112.1 NZ_LT608330:3585786-3586340 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References