Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1887458..1888966 Replicon chromosome
Accession NZ_LT608330
Organism Pseudomonas aeruginosa isolate PA14Or_reads

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PHAGEPCYII10_RS08735 Protein ID WP_003119682.1
Coordinates 1887458..1888045 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag PHAGEPCYII10_RS08740 Protein ID WP_003091607.1
Coordinates 1888112..1888966 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHAGEPCYII10_RS08730 1883713..1887192 - 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -
PHAGEPCYII10_RS08735 1887458..1888045 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
PHAGEPCYII10_RS08740 1888112..1888966 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
PHAGEPCYII10_RS08745 1889063..1891228 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
PHAGEPCYII10_RS08750 1891403..1893277 + 1875 WP_003138346.1 MFS transporter -
PHAGEPCYII10_RS08755 1893338..1893547 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T293302 WP_003119682.1 NZ_LT608330:1887458-1888045 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT293302 WP_003091607.1 NZ_LT608330:1888112-1888966 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References