Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141482..141987 Replicon chromosome
Accession NZ_LT608330
Organism Pseudomonas aeruginosa isolate PA14Or_reads

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PHAGEPCYII10_RS00630 Protein ID WP_003083773.1
Coordinates 141482..141763 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag PHAGEPCYII10_RS00635 Protein ID WP_003137009.1
Coordinates 141760..141987 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHAGEPCYII10_RS00605 136733..138082 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
PHAGEPCYII10_RS00610 138131..138817 + 687 WP_003083762.1 FadR family transcriptional regulator -
PHAGEPCYII10_RS00615 138918..139652 + 735 WP_003110658.1 GntR family transcriptional regulator -
PHAGEPCYII10_RS00620 139856..140242 + 387 WP_003083767.1 aegerolysin family protein -
PHAGEPCYII10_RS00625 140274..141182 - 909 WP_003083769.1 LysR family transcriptional regulator -
PHAGEPCYII10_RS00630 141482..141763 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PHAGEPCYII10_RS00635 141760..141987 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
PHAGEPCYII10_RS00640 142163..142786 - 624 WP_003137011.1 hypothetical protein -
PHAGEPCYII10_RS00645 142887..143387 + 501 WP_003137013.1 LEA type 2 family protein -
PHAGEPCYII10_RS00650 143459..143800 + 342 WP_003101229.1 alkylphosphonate utilization protein -
PHAGEPCYII10_RS00655 143882..145309 - 1428 WP_003137015.1 GABA permease -
PHAGEPCYII10_RS00660 145478..146971 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T293300 WP_003083773.1 NZ_LT608330:c141763-141482 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT293300 WP_003137009.1 NZ_LT608330:c141987-141760 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References