Detailed information of TA system TA029330

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2187563..2188204
• Replicon: draft genome
• Accession: NC_021010
• Organism: Eubacterium rectale DSM 17629

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EUR_RS10445
• Protein ID: WP_012741957.1
• Coordinates: 2188013..2188204 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EUR_RS10440
• Protein ID: WP_012741956.1
• Coordinates: 2187563..2187991 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EUR_RS10420 (EUR_21160)	2183689..2184447	-	759	WP_015516931.1	DUF4866 domain-containing protein	-
EUR_RS10425 (EUR_21170)	2184638..2185534	+	897	WP_015516932.1	LysR family transcriptional regulator	-
EUR_RS10430 (EUR_21180)	2185728..2186873	+	1146	WP_015516933.1	lactaldehyde reductase	-
EUR_RS10435 (EUR_21190)	2186984..2187535	-	552	WP_015516934.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
EUR_RS10440 (EUR_21200)	2187563..2187991	-	429	WP_012741956.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EUR_RS10445 (EUR_21210)	2188013..2188204	-	192	WP_012741957.1	type II toxin-antitoxin system HicA family toxin	Toxin
EUR_RS10450 (EUR_21220)	2188449..2189885	+	1437	WP_015516935.1	MATE family efflux transporter	-
EUR_RS10455 (EUR_21230)	2189905..2190555	-	651	WP_015516936.1	cupin domain-containing protein	-
EUR_RS10460	2191744..2191998	-	255	WP_306775837.1	hypothetical protein	-
EUR_RS10465 (EUR_21260)	2192042..2192503	-	462	WP_015516938.1	SpoVA/SpoVAEb family sporulation membrane protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2174831..2305355	130524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (7-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-115)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7247.50 Da
• Isoelectric Point: 10.9086

>T29330 WP_012741957.1 NC_021010:c2188204-2188013 [Agathobacter rectalis DSM 17629]
MPIKPTEMERIILADGWIFKNQTGSHRHYIHPSKPGKVTIPFHKGKELNKITENSIRKQAGIK

Nucleotide

• Length: 192 bp

>T29330 NC_021010:c2188204-2188013 [Agathobacter rectalis DSM 17629]
ATGCCGATCAAACCAACTGAAATGGAACGTATAATACTTGCCGATGGGTGGATTTTCAAAAACCAAACCGGATCACATCG
GCATTATATTCATCCTTCAAAGCCCGGAAAAGTAACCATTCCTTTTCATAAAGGCAAAGAACTGAACAAAATCACTGAAA
ATTCTATCCGTAAGCAAGCGGGAATCAAATAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15853.00 Da
• Isoelectric Point: 4.4976

>AT29330 WP_012741956.1 NC_021010:c2187991-2187563 [Agathobacter rectalis DSM 17629]
MLSIYPACFFKEDNGYSVIFPDLNYLATQGDTLEDAVAMAVDCLAGYLYTAKMDNEKFPKASKLSDINIDRLSDELDITG
TYTDAFTNMVSVDVKAYAKEHFDKSVRKTLTIPAWLNTAAQEEGINFSKTLQEALMSKLKAH

Nucleotide

• Length: 429 bp

>AT29330 NC_021010:c2187991-2187563 [Agathobacter rectalis DSM 17629]
ATGTTATCAATATATCCGGCATGTTTTTTTAAGGAAGATAATGGATACTCTGTAATCTTTCCTGATTTAAATTATCTTGC
AACACAAGGAGATACCCTTGAAGATGCTGTGGCCATGGCTGTTGATTGTCTTGCAGGATATCTGTATACGGCTAAGATGG
ATAATGAAAAATTTCCTAAAGCATCCAAATTATCTGATATCAATATTGACAGACTATCTGACGAATTAGACATAACAGGA
ACATATACCGATGCATTTACCAATATGGTTTCAGTAGATGTTAAGGCATATGCCAAAGAGCATTTCGATAAATCGGTCCG
AAAAACCCTTACCATTCCGGCTTGGCTAAATACTGCTGCGCAGGAAGAGGGAATTAATTTTTCAAAAACACTGCAGGAAG
CACTTATGTCAAAGCTTAAGGCTCATTAG