Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1181449..1182032 Replicon chromosome
Accession NZ_LT606946
Organism Polynucleobacter necessarius isolate PPGSP5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DXE44_RS06130 Protein ID WP_114653504.1
Coordinates 1181838..1182032 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DXE44_RS06125 Protein ID WP_114653502.1
Coordinates 1181449..1181841 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE44_RS06100 1177213..1178181 + 969 WP_114653492.1 tripartite tricarboxylate transporter substrate binding protein BugE -
DXE44_RS06105 1178323..1178604 - 282 WP_162785890.1 hypothetical protein -
DXE44_RS06110 1178615..1179148 - 534 WP_162785891.1 hypothetical protein -
DXE44_RS10100 1179325..1179675 - 351 WP_162785892.1 hypothetical protein -
DXE44_RS06115 1179868..1180245 + 378 WP_114653498.1 glycosyltransferase -
DXE44_RS06120 1180287..1181393 + 1107 WP_114653499.1 HAD-IB family phosphatase -
DXE44_RS06125 1181449..1181841 - 393 WP_114653502.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DXE44_RS06130 1181838..1182032 - 195 WP_114653504.1 type II toxin-antitoxin system HicA family toxin Toxin
DXE44_RS06135 1182077..1184479 - 2403 WP_162785920.1 DNA internalization-related competence protein ComEC/Rec2 -
DXE44_RS06140 1184571..1185431 - 861 WP_114653505.1 TatD family hydrolase -
DXE44_RS06145 1185428..1186099 - 672 WP_114654376.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1177213..1191294 14081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7299.58 Da        Isoelectric Point: 10.8795

>T293295 WP_114653504.1 NZ_LT606946:c1182032-1181838 [Polynucleobacter necessarius]
MHSKKLIELLSSDGWVLSRTRGSHHIFTHRTKDGHICIPHPKKDLGLGLVEKILKQADIKRGHK

Download         Length: 195 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14503.74 Da        Isoelectric Point: 5.0435

>AT293295 WP_114653502.1 NZ_LT606946:c1181841-1181449 [Polynucleobacter necessarius]
MKYPIAIEPGSSKEAWGVVVPDLAGCFSAGDRDIDEAIENAKEAIEIWIELALERNQEIPKPSSLRELQKRKEFKGWVWA
IVEIDPALLSDEIERINITLPKRVLARLDAKAKKAGENRSAFIAHLALTA

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References