Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-TIGR02293
Location 160919..161904 Replicon chromosome
Accession NZ_LT606946
Organism Polynucleobacter necessarius isolate PPGSP5

Toxin (Protein)


Gene name ParT Uniprot ID -
Locus tag DXE44_RS00860 Protein ID WP_114651892.1
Coordinates 161416..161904 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID -
Locus tag DXE44_RS00855 Protein ID WP_114651890.1
Coordinates 160919..161419 (+) Length 167 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE44_RS00815 155996..157111 + 1116 WP_114651874.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
DXE44_RS00820 157165..157782 + 618 WP_114651876.1 riboflavin synthase -
DXE44_RS00825 157746..157961 - 216 WP_114651878.1 hypothetical protein -
DXE44_RS00830 158062..158370 + 309 WP_114651880.1 type II toxin-antitoxin system HigB family toxin -
DXE44_RS00835 158367..158735 + 369 WP_114651882.1 transcriptional regulator -
DXE44_RS00840 158741..159487 - 747 WP_114651884.1 7-cyano-7-deazaguanine synthase QueC -
DXE44_RS00845 159517..160248 - 732 WP_114651886.1 tol-pal system protein YbgF -
DXE44_RS00850 160248..160748 - 501 WP_114651888.1 peptidoglycan-associated lipoprotein Pal -
DXE44_RS00855 160919..161419 + 501 WP_114651890.1 DUF2384 domain-containing protein Antitoxin
DXE44_RS00860 161416..161904 + 489 WP_114651892.1 RES family NAD+ phosphorylase Toxin
DXE44_RS00865 161918..163174 - 1257 WP_114654294.1 Tol-Pal system protein TolB -
DXE44_RS00870 163233..163961 - 729 WP_114651894.1 cell envelope integrity protein TolA -
DXE44_RS00875 163981..164400 - 420 WP_114651896.1 ExbD/TolR family protein -
DXE44_RS00880 164403..165059 - 657 WP_114651898.1 protein TolQ -
DXE44_RS00885 165136..166380 + 1245 WP_114654295.1 serine hydroxymethyltransferase -
DXE44_RS00890 166422..166868 + 447 WP_114651900.1 transcriptional regulator NrdR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(6-152)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(38-98)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17801.77 Da        Isoelectric Point: 10.2145

>T293292 WP_114651892.1 NZ_LT606946:161416-161904 [Polynucleobacter necessarius]
MSVQVVWRIALDAPTFKADDLSGEGAKKSGGRWNKKGTPVLYTSESIALACLETLVHINAQGLPLNRYLVRIDIPTKVWD
MAKKFNFKTAGFGWDALPAGTVSIDKGEKWLQSNASALLFVPSVVIPQASNVLINPLHPDTKLIKAKKIEKFSYDPRLVS
LP

Download         Length: 489 bp

Antitoxin


Download         Length: 167 a.a.        Molecular weight: 18057.95 Da        Isoelectric Point: 10.0191

>AT293292 WP_114651890.1 NZ_LT606946:160919-161419 [Polynucleobacter necessarius]
MSSVIAKKPGTKVTRKNLVAGVQSDFSFAQIYRVQPIDRIRLMRTGVPARYINVIADSMGITKDTLFRYLNLPRSTVDKK
LAASQILPIEQGERLIGMAKLVGQVESMIAESGNPDGFDAAKWVASWLEKPSPALGGEKPSAYLDTISGQEMISDLLAKI
QTGAYA

Download         Length: 501 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References