Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1900875..1901545 Replicon chromosome
Accession NZ_LT605585
Organism Brucella inopinata strain 141012304 isolate Brucella sp.

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BR141012304_RS09040 Protein ID WP_008504608.1
Coordinates 1900875..1901279 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D1CXH4
Locus tag BR141012304_RS09045 Protein ID WP_008504606.1
Coordinates 1901276..1901545 (-) Length 90 a.a.

Genomic Context


BR141012304_RS09015BR141012304_RS09020BR141012304_RS09025BR141012304_RS09055BR141012304_RS09060BR141012304_RS09030BR141012304_RS09035BR141012304_RS09040BR141012304_RS09045BR141012304_RS09050BR141012304_RS09065
Location: 1896546..1896779 (234 bp)
Type: Others
Protein ID: WP_002963968.1
Location: 1896964..1897296 (333 bp)
Type: Others
Protein ID: WP_008505520.1
Location: 1897565..1898830 (1266 bp)
Type: Others
Protein ID: WP_070997981.1
Location: 1902627..1903598 (972 bp)
Type: Others
Protein ID: WP_070997983.1
Location: 1903870..1904283 (414 bp)
Type: Others
Protein ID: WP_008935646.1
Location: 1898884..1899711 (828 bp)
Type: Others
Protein ID: WP_070997982.1
Location: 1899698..1900579 (882 bp)
Type: Others
Protein ID: WP_002969416.1
Location: 1900875..1901279 (405 bp)
Type: Toxin
Protein ID: WP_008504608.1
Location: 1901276..1901545 (270 bp)
Type: Antitoxin
Protein ID: WP_008504606.1
Location: 1901675..1902292 (618 bp)
Type: Others
Protein ID: WP_002967582.1
Location: 1904328..1904525 (198 bp)
Type: Others
Protein ID: WP_070997719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BR141012304_RS090151896546..1896779+234WP_002963968.1BolA family transcriptional regulator-
BR141012304_RS090201896964..1897296+333WP_008505520.1Grx4 family monothiol glutaredoxin-
BR141012304_RS090251897565..1898830+1266WP_070997981.1multidrug effflux MFS transporter-
BR141012304_RS090301898884..1899711-828WP_070997982.1inositol monophosphatase family protein-
BR141012304_RS090351899698..1900579-882WP_002969416.1tRNA 2-thiocytidine(32) synthetase TtcA-
BR141012304_RS090401900875..1901279-405WP_008504608.1type II toxin-antitoxin system VapC family toxinToxin
BR141012304_RS090451901276..1901545-270WP_008504606.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
BR141012304_RS090501901675..1902292-618WP_002967582.130S ribosomal protein S4-
BR141012304_RS090551902627..1903598+972WP_070997983.1extensin family protein-
BR141012304_RS090601903870..1904283+414WP_008935646.1hypothetical protein-
BR141012304_RS090651904328..1904525-198WP_070997719.1DUF3008 family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-118)

Antitoxin

(18-55)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 14365.66 Da        Isoelectric Point: 5.6366

>T293290 WP_008504608.1 NZ_LT605585:c1901279-1900875 [Brucella inopinata]
MSKLYMLDTNIVSDLARNPHGPVAKHIARVGADAICVSIITACELRYGCAKKGSPRLLAQIEAILDSIEILPLDVPADTE
YGGIRAELEADGKPIGPNDFLIAAHAYALGAVLVTANVGEFTRIRKLAVENWLN

Download         Length: 405 bp


Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10046.62 Da        Isoelectric Point: 7.2059

>AT293290 WP_008504606.1 NZ_LT605585:c1901545-1901276 [Brucella inopinata]
MAHARRIEPTPAREAKLFRNNKSQAVRIPADFEFPGNRVLIHREGDKLIIEPVRRKNLLEVLAGLKPLGPEDAFPDIDDT
ALPLKDVDL

Download         Length: 270 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7L7MKG1

References