Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 605362..605998 Replicon chromosome
Accession NZ_LT603683
Organism Bacillus glycinifermentans isolate BGLY

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag BGLY_RS03005 Protein ID WP_003179128.1
Coordinates 605648..605998 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A6I7F8B4
Locus tag BGLY_RS03000 Protein ID WP_026585993.1
Coordinates 605362..605643 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGLY_RS02980 600524..602005 + 1482 WP_046132202.1 PH domain-containing protein -
BGLY_RS02985 602002..602601 - 600 WP_046132201.1 rhomboid family intramembrane serine protease -
BGLY_RS02990 602883..603899 + 1017 WP_099047092.1 outer membrane lipoprotein carrier protein LolA -
BGLY_RS02995 604093..605253 + 1161 WP_046132199.1 alanine racemase -
BGLY_RS03000 605362..605643 + 282 WP_026585993.1 hypothetical protein Antitoxin
BGLY_RS03005 605648..605998 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BGLY_RS03010 606072..606941 + 870 WP_173427511.1 STAS domain-containing protein -
BGLY_RS03015 606944..607309 + 366 WP_046132197.1 STAS domain-containing protein -
BGLY_RS03020 607312..607713 + 402 WP_046132196.1 anti-sigma regulatory factor -
BGLY_RS03025 607724..608731 + 1008 WP_046132195.1 PP2C family protein-serine/threonine phosphatase -
BGLY_RS03030 608790..609116 + 327 WP_046132194.1 anti-sigma factor antagonist -
BGLY_RS03035 609116..609598 + 483 WP_046132193.1 anti-sigma B factor RsbW -
BGLY_RS03040 609564..610355 + 792 WP_046132218.1 RNA polymerase sigma factor SigB -
BGLY_RS03045 610352..610951 + 600 WP_046132192.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T293284 WP_003179128.1 NZ_LT603683:605648-605998 [Bacillus glycinifermentans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10667.07 Da        Isoelectric Point: 4.6920

>AT293284 WP_026585993.1 NZ_LT603683:605362-605643 [Bacillus glycinifermentans]
MSESSATTEIMIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB A0A6I7F8B4

References