Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5043606..5044438 Replicon chromosome
Accession NZ_LT601384
Organism Escherichia coli isolate NCTC86EC

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag NCTC86EC_RS24835 Protein ID WP_058101701.1
Coordinates 5044064..5044438 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag NCTC86EC_RS24830 Protein ID WP_001540478.1
Coordinates 5043606..5043974 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC86EC_RS24795 5040724..5040870 + 147 WP_059333225.1 DUF905 family protein -
NCTC86EC_RS24800 5041037..5041855 + 819 WP_001234716.1 DUF945 domain-containing protein -
NCTC86EC_RS28935 5041855..5042028 + 174 WP_001183321.1 hypothetical protein -
NCTC86EC_RS24810 5042194..5042667 + 474 WP_068879497.1 antirestriction protein -
NCTC86EC_RS24815 5042683..5043159 + 477 WP_001186786.1 RadC family protein -
NCTC86EC_RS24820 5043222..5043443 + 222 WP_021532904.1 DUF987 domain-containing protein -
NCTC86EC_RS24830 5043606..5043974 + 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NCTC86EC_RS24835 5044064..5044438 + 375 WP_058101701.1 TA system toxin CbtA family protein Toxin
NCTC86EC_RS24840 5044435..5044926 + 492 WP_001586604.1 hypothetical protein -
NCTC86EC_RS24845 5044943..5045119 + 177 WP_001586605.1 DUF957 domain-containing protein -
NCTC86EC_RS29030 5045219..5045377 + 159 WP_001467148.1 hypothetical protein -
NCTC86EC_RS24850 5046030..5048921 + 2892 WP_000580534.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimB / fimE 5037807..5063988 26181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13796.72 Da        Isoelectric Point: 7.9047

>T293282 WP_058101701.1 NZ_LT601384:5044064-5044438 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT293282 WP_001540478.1 NZ_LT601384:5043606-5043974 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References