Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1461039..1461677 Replicon chromosome
Accession NZ_LT601384
Organism Escherichia coli isolate NCTC86EC

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NCTC86EC_RS06965 Protein ID WP_000813794.1
Coordinates 1461501..1461677 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NCTC86EC_RS06960 Protein ID WP_001270286.1
Coordinates 1461039..1461455 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC86EC_RS06940 1456191..1457132 - 942 WP_001251304.1 ABC transporter permease -
NCTC86EC_RS06945 1457133..1458146 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NCTC86EC_RS06950 1458164..1459309 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NCTC86EC_RS06955 1459554..1460960 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
NCTC86EC_RS06960 1461039..1461455 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NCTC86EC_RS06965 1461501..1461677 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NCTC86EC_RS06970 1461899..1462129 + 231 WP_000494244.1 YncJ family protein -
NCTC86EC_RS06975 1462221..1464182 - 1962 WP_066009051.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NCTC86EC_RS06980 1464255..1464791 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NCTC86EC_RS06985 1464844..1466058 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T293266 WP_000813794.1 NZ_LT601384:c1461677-1461501 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT293266 WP_001270286.1 NZ_LT601384:c1461455-1461039 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References