293251

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2192593..2193122 Replicon chromosome
Accession NZ_LT598688
Organism Staphylococcus aureus isolate Sa_Newman_UoM

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BN8422_RS11430 Protein ID WP_000621175.1
Coordinates 2192593..2192955 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag BN8422_RS11435 Protein ID WP_000948331.1
Coordinates 2192952..2193122 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN8422_RS11405 2189570..2190340 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
BN8422_RS11410 2190315..2190794 - 480 WP_001190829.1 anti-sigma B factor RsbW -
BN8422_RS11415 2190796..2191122 - 327 WP_001052491.1 anti-sigma factor antagonist -
BN8422_RS11420 2191242..2192243 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
BN8422_RS11430 2192593..2192955 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BN8422_RS11435 2192952..2193122 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
BN8422_RS11440 2193207..2194355 - 1149 WP_001281145.1 alanine racemase -
BN8422_RS11445 2194421..2194780 - 360 WP_000581200.1 holo-ACP synthase -
BN8422_RS11450 2194784..2195275 - 492 WP_001205910.1 PH domain-containing protein -
BN8422_RS11455 2195262..2196845 - 1584 WP_001294631.1 PH domain-containing protein -
BN8422_RS11460 2196838..2197317 - 480 WP_001287088.1 hypothetical protein -
BN8422_RS11465 2197526..2198086 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T293251 WP_000621175.1 NZ_LT598688:c2192955-2192593 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT293251 WP_000948331.1 NZ_LT598688:c2193122-2192952 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References