Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 81134..81662 Replicon plasmid 2
Accession NZ_LT598658
Organism Legionella pneumophila strain Lpm7613 isolate Lpm7613

Toxin (Protein)


Gene name relE Uniprot ID A0A0A8UYT5
Locus tag LPM7613_RS14865 Protein ID WP_011212544.1
Coordinates 81134..81421 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A8UU85
Locus tag LPM7613_RS14870 Protein ID WP_011212545.1
Coordinates 81411..81662 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPM7613_RS14835 76441..77949 + 1509 WP_011212538.1 DUF3987 domain-containing protein -
LPM7613_RS14840 78000..78575 + 576 WP_011212539.1 pyridoxamine 5'-phosphate oxidase family protein -
LPM7613_RS14845 78584..78895 + 312 WP_011212540.1 hypothetical protein -
LPM7613_RS14850 78951..79133 + 183 WP_011212541.1 hypothetical protein -
LPM7613_RS14855 79227..80102 - 876 WP_061468560.1 alpha/beta hydrolase -
LPM7613_RS14860 80160..80921 - 762 WP_011212543.1 MerR family transcriptional regulator -
LPM7613_RS14865 81134..81421 - 288 WP_011212544.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPM7613_RS14870 81411..81662 - 252 WP_011212545.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LPM7613_RS14875 81911..82378 - 468 WP_011212546.1 hypothetical protein -
LPM7613_RS14880 82997..83818 - 822 WP_011212547.1 DUF4111 domain-containing protein -
LPM7613_RS14885 83802..84239 - 438 WP_010655396.1 DNA-binding protein -
LPM7613_RS14890 84226..84804 - 579 WP_010655397.1 nucleotidyltransferase domain-containing protein -
LPM7613_RS14895 85092..85973 - 882 WP_021436862.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-29 - 1..129881 129881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-68)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11302.35 Da        Isoelectric Point: 10.4380

>T293239 WP_011212544.1 NZ_LT598658:c81421-81134 [Legionella pneumophila]
MIYELHFHPLALKEWKKLSKELQEQFKKLLKRRLENPHVISAKLSGHLKDCYKIKLHQAGYRLVYQVNDNKMILLVVAVG
KRNKNKVYESAEDRT

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.58 Da        Isoelectric Point: 4.5164

>AT293239 WP_011212545.1 NZ_LT598658:c81662-81411 [Legionella pneumophila]
MQTLYATQVASISELKKNPTKLINDAHGMPVVILNHNVAAAYLIPAETFEKLMDAVDESELKSIVEQRLSEPFTPVKVAL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8UYT5

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8UU85

References