Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3454916..3455536 Replicon chromosome
Accession NZ_LT596221
Organism Yersinia pseudotuberculosis isolate NZYP4713

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag BN7064_RS15720 Protein ID WP_002208622.1
Coordinates 3455333..3455536 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag BN7064_RS15715 Protein ID WP_002218472.1
Coordinates 3454916..3455284 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN7064_RS15700 3453120..3453380 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
BN7064_RS15705 3453396..3453539 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
BN7064_RS15710 3454404..3454757 + 354 WP_057534133.1 hypothetical protein -
BN7064_RS15715 3454916..3455284 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
BN7064_RS15720 3455333..3455536 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
BN7064_RS15730 3456442..3456831 + 390 WP_002208623.1 MGMT family protein -
BN7064_RS15735 3456967..3457488 - 522 WP_012413513.1 YbaY family lipoprotein -
BN7064_RS15740 3457745..3458605 + 861 WP_002208625.1 acyl-CoA thioesterase II -
BN7064_RS15745 3458867..3460156 - 1290 WP_002228344.1 ammonium transporter AmtB -
BN7064_RS15750 3460196..3460534 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T293236 WP_002208622.1 NZ_LT596221:3455333-3455536 [Yersinia pseudotuberculosis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT293236 WP_002218472.1 NZ_LT596221:3454916-3455284 [Yersinia pseudotuberculosis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References