Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2039971..2040988 Replicon chromosome
Accession NZ_LT596221
Organism Yersinia pseudotuberculosis isolate NZYP4713

Toxin (Protein)


Gene name - Uniprot ID Q66A68
Locus tag BN7064_RS09240 Protein ID WP_011192520.1
Coordinates 2039971..2040429 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag BN7064_RS09245 Protein ID WP_002210982.1
Coordinates 2040542..2040988 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN7064_RS09210 2035785..2036450 + 666 WP_002210975.1 phage shock protein PspA -
BN7064_RS09215 2036612..2036839 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
BN7064_RS09220 2036839..2037198 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
BN7064_RS09225 2037283..2037525 + 243 WP_002216375.1 phage shock protein PspD -
BN7064_RS09230 2037506..2038903 + 1398 WP_012105043.1 YcjX family protein -
BN7064_RS09235 2038900..2039961 + 1062 WP_012413752.1 YcjF family protein -
BN7064_RS09240 2039971..2040429 - 459 WP_011192520.1 RES family NAD+ phosphorylase Toxin
BN7064_RS09245 2040542..2040988 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
BN7064_RS09250 2041325..2042902 + 1578 WP_011192519.1 transcriptional regulator TyrR -
BN7064_RS09255 2043066..2043569 - 504 WP_002210984.1 thiol peroxidase -
BN7064_RS09260 2043732..2044712 + 981 WP_012413751.1 L-Ala-D/L-Glu epimerase -
BN7064_RS09265 2044754..2045461 - 708 WP_038823925.1 murein tripeptide amidase MpaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17008.41 Da        Isoelectric Point: 4.8732

>T293231 WP_011192520.1 NZ_LT596221:c2040429-2039971 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT293231 WP_002210982.1 NZ_LT596221:c2040988-2040542 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q66A68

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References