Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /COG5642-COG5654 |
| Location | 2039971..2040988 | Replicon | chromosome |
| Accession | NZ_LT596221 | ||
| Organism | Yersinia pseudotuberculosis isolate NZYP4713 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q66A68 |
| Locus tag | BN7064_RS09240 | Protein ID | WP_011192520.1 |
| Coordinates | 2039971..2040429 (-) | Length | 153 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | Q66A69 |
| Locus tag | BN7064_RS09245 | Protein ID | WP_002210982.1 |
| Coordinates | 2040542..2040988 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BN7064_RS09210 | 2035785..2036450 | + | 666 | WP_002210975.1 | phage shock protein PspA | - |
| BN7064_RS09215 | 2036612..2036839 | + | 228 | WP_002210976.1 | envelope stress response membrane protein PspB | - |
| BN7064_RS09220 | 2036839..2037198 | + | 360 | WP_002210977.1 | envelope stress response membrane protein PspC | - |
| BN7064_RS09225 | 2037283..2037525 | + | 243 | WP_002216375.1 | phage shock protein PspD | - |
| BN7064_RS09230 | 2037506..2038903 | + | 1398 | WP_012105043.1 | YcjX family protein | - |
| BN7064_RS09235 | 2038900..2039961 | + | 1062 | WP_012413752.1 | YcjF family protein | - |
| BN7064_RS09240 | 2039971..2040429 | - | 459 | WP_011192520.1 | RES family NAD+ phosphorylase | Toxin |
| BN7064_RS09245 | 2040542..2040988 | - | 447 | WP_002210982.1 | DUF2384 domain-containing protein | Antitoxin |
| BN7064_RS09250 | 2041325..2042902 | + | 1578 | WP_011192519.1 | transcriptional regulator TyrR | - |
| BN7064_RS09255 | 2043066..2043569 | - | 504 | WP_002210984.1 | thiol peroxidase | - |
| BN7064_RS09260 | 2043732..2044712 | + | 981 | WP_012413751.1 | L-Ala-D/L-Glu epimerase | - |
| BN7064_RS09265 | 2044754..2045461 | - | 708 | WP_038823925.1 | murein tripeptide amidase MpaA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 153 a.a. Molecular weight: 17008.41 Da Isoelectric Point: 4.8732
>T293231 WP_011192520.1 NZ_LT596221:c2040429-2039971 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK
Download Length: 459 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16401.94 Da Isoelectric Point: 9.7155
>AT293231 WP_002210982.1 NZ_LT596221:c2040988-2040542 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q66A68 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E8XFL1 |