Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1017575..1018247 Replicon chromosome
Accession NZ_LT596221
Organism Yersinia pseudotuberculosis isolate NZYP4713

Toxin (Protein)


Gene name cptA Uniprot ID A0A0U1R236
Locus tag BN7064_RS04505 Protein ID WP_012104676.1
Coordinates 1017822..1018247 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag BN7064_RS04500 Protein ID WP_002209939.1
Coordinates 1017575..1017841 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN7064_RS04480 1013398..1014501 + 1104 WP_012413926.1 hypothetical protein -
BN7064_RS04485 1014703..1015404 + 702 WP_057534195.1 hemolysin III family protein -
BN7064_RS04490 1015696..1016193 + 498 WP_002209941.1 DUF2165 family protein -
BN7064_RS04495 1016266..1017258 - 993 WP_012413924.1 tRNA-modifying protein YgfZ -
BN7064_RS04500 1017575..1017841 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
BN7064_RS04505 1017822..1018247 + 426 WP_012104676.1 protein YgfX Toxin
BN7064_RS04510 1018247..1018945 + 699 WP_002209937.1 two-component system response regulator CreB -
BN7064_RS04515 1018970..1020388 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
BN7064_RS04520 1020509..1021966 + 1458 WP_032466588.1 cell envelope integrity protein CreD -
BN7064_RS04525 1022051..1022569 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16467.40 Da        Isoelectric Point: 10.1176

>T293230 WP_012104676.1 NZ_LT596221:1017822-1018247 [Yersinia pseudotuberculosis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVLWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT293230 WP_002209939.1 NZ_LT596221:1017575-1017841 [Yersinia pseudotuberculosis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1R236

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References