Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3488358..3488983 Replicon chromosome
Accession NZ_LT594504
Organism Escherichia coli isolate E. coli RL465

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RL465_RS16850 Protein ID WP_000911330.1
Coordinates 3488358..3488756 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag RL465_RS16855 Protein ID WP_000450524.1
Coordinates 3488756..3488983 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL465_RS16830 3484236..3484436 + 201 WP_000383836.1 YpfN family protein -
RL465_RS16835 3484546..3485244 - 699 WP_000679823.1 esterase -
RL465_RS16840 3485318..3487333 - 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
RL465_RS16845 3487348..3488211 - 864 WP_001267507.1 neutral zinc metallopeptidase -
RL465_RS16850 3488358..3488756 - 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
RL465_RS16855 3488756..3488983 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
RL465_RS16860 3489137..3489850 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
RL465_RS16865 3490063..3491097 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
RL465_RS16870 3491114..3491992 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
RL465_RS16875 3492138..3492710 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
RL465_RS16880 3492710..3493180 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T293221 WP_000911330.1 NZ_LT594504:c3488756-3488358 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT293221 WP_000450524.1 NZ_LT594504:c3488983-3488756 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References