Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1372354..1372972 Replicon chromosome
Accession NZ_LT594504
Organism Escherichia coli isolate E. coli RL465

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag RL465_RS06645 Protein ID WP_001291435.1
Coordinates 1372354..1372572 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag RL465_RS06650 Protein ID WP_000344800.1
Coordinates 1372598..1372972 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL465_RS06610 1367643..1368215 + 573 WP_000779831.1 YbaY family lipoprotein -
RL465_RS06615 1368246..1368557 - 312 WP_000409911.1 MGMT family protein -
RL465_RS06625 1368936..1369289 + 354 WP_000878140.1 DUF1428 domain-containing protein -
RL465_RS06630 1369331..1370881 - 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
RL465_RS06635 1371045..1371515 - 471 WP_000136192.1 YlaC family protein -
RL465_RS06640 1371631..1372182 - 552 WP_000102568.1 maltose O-acetyltransferase -
RL465_RS06645 1372354..1372572 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
RL465_RS06650 1372598..1372972 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
RL465_RS06655 1373518..1376667 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
RL465_RS06660 1376690..1377883 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T293214 WP_001291435.1 NZ_LT594504:c1372572-1372354 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT293214 WP_000344800.1 NZ_LT594504:c1372972-1372598 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References