Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 581928..582726 Replicon chromosome
Accession NZ_LT594504
Organism Escherichia coli isolate E. coli RL465

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag RL465_RS02830 Protein ID WP_074417329.1
Coordinates 581928..582305 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1L4NTN5
Locus tag RL465_RS02835 Protein ID WP_001605875.1
Coordinates 582352..582726 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL465_RS02810 578020..579558 - 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -
RL465_RS02815 580307..581149 - 843 WP_074417327.1 DUF4942 domain-containing protein -
RL465_RS02820 581234..581431 - 198 WP_074417334.1 DUF957 domain-containing protein -
RL465_RS02825 581443..581931 - 489 WP_074417328.1 hypothetical protein -
RL465_RS02830 581928..582305 - 378 WP_074417329.1 TA system toxin CbtA family protein Toxin
RL465_RS02835 582352..582726 - 375 WP_001605875.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
RL465_RS02840 582800..583021 - 222 WP_074417330.1 DUF987 domain-containing protein -
RL465_RS02845 583090..583566 - 477 WP_001186725.1 RadC family protein -
RL465_RS02850 583582..584067 - 486 WP_074417331.1 antirestriction protein -
RL465_RS02855 584158..584976 - 819 WP_074417332.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 570531..599673 29142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14206.19 Da        Isoelectric Point: 8.2905

>T293213 WP_074417329.1 NZ_LT594504:c582305-581928 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13594.42 Da        Isoelectric Point: 5.4554

>AT293213 WP_001605875.1 NZ_LT594504:c582726-582352 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLACEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4NTN5

References