Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta(toxin)
Location 8802..10453 Replicon plasmid 2
Accession NZ_LT592164
Organism Neisseria gonorrhoeae strain WHO_W

Toxin (Protein)


Gene name ng_zeta1 Uniprot ID D5K9G7
Locus tag C7S03_RS13150 Protein ID WP_003701905.1
Coordinates 8802..10007 (+) Length 402 a.a.

Antitoxin (Protein)


Gene name ng_epsilon1 Uniprot ID D5K9G8
Locus tag C7S03_RS13155 Protein ID WP_003701903.1
Coordinates 10022..10453 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7S03_RS13115 4390..4758 + 369 WP_003701920.1 hypothetical protein -
C7S03_RS13120 4742..5113 + 372 WP_003701919.1 hypothetical protein -
C7S03_RS13125 5117..6013 + 897 WP_003701917.1 hypothetical protein -
C7S03_RS13130 6165..6653 - 489 WP_014580055.1 hypothetical protein -
C7S03_RS13135 7123..7371 + 249 WP_014580056.1 hypothetical protein -
C7S03_RS13140 7368..8576 + 1209 WP_014580057.1 zeta toxin family protein -
C7S03_RS13145 8610..8795 + 186 WP_014580058.1 hypothetical protein -
C7S03_RS13150 8802..10007 + 1206 WP_003701905.1 toxin Toxin
C7S03_RS13155 10022..10453 + 432 WP_003701903.1 hypothetical protein Antitoxin
C7S03_RS13160 10505..11059 + 555 WP_003701901.1 recombinase family protein -
C7S03_RS13165 11169..11459 - 291 WP_003701899.1 virulence factor -
C7S03_RS13170 11562..12161 - 600 WP_003701898.1 TrbN protein -
C7S03_RS13175 12161..12679 - 519 WP_025456271.1 TrbM protein -
C7S03_RS13180 12726..14354 - 1629 WP_003701894.1 P-type conjugative transfer protein TrbL -
C7S03_RS13185 14568..15344 - 777 WP_003701891.1 P-type conjugative transfer protein TrbJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..39054 39054


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

KfrB domain

(284-343)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 402 a.a.        Molecular weight: 44675.53 Da        Isoelectric Point: 7.7756

>T293209 WP_003701905.1 NZ_LT592164:8802-10007 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R

Download         Length: 1206 bp

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15927.05 Da        Isoelectric Point: 4.4211

>AT293209 WP_003701903.1 NZ_LT592164:10022-10453 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ

Download         Length: 432 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6EPI
PDB 6EPG
PDB 6EPH

Antitoxin

Source ID Structure
AlphaFold DB D5K9G8

References