Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1016303..1016958 Replicon chromosome
Accession NZ_LT592163
Organism Neisseria gonorrhoeae strain WHO_W

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag C7S03_RS05815 Protein ID WP_003691083.1
Coordinates 1016303..1016722 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag C7S03_RS05820 Protein ID WP_003688410.1
Coordinates 1016722..1016958 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7S03_RS05795 1011537..1013078 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
C7S03_RS05800 1013226..1014005 + 780 WP_003688416.1 (Fe-S)-binding protein -
C7S03_RS05805 1014002..1014703 + 702 WP_003688414.1 lactate utilization protein C -
C7S03_RS05810 1014700..1016154 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
C7S03_RS05815 1016303..1016722 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
C7S03_RS05820 1016722..1016958 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
C7S03_RS05825 1017164..1017361 - 198 WP_033910354.1 IS3 family transposase -
C7S03_RS05830 1017406..1017984 - 579 WP_003688041.1 IS3 family transposase -
C7S03_RS05835 1017989..1018417 - 429 WP_003701165.1 helix-turn-helix domain-containing protein -
C7S03_RS05840 1018629..1019015 + 387 Protein_1031 IS110 family transposase -
C7S03_RS05845 1019398..1020288 - 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
C7S03_RS05850 1020299..1021465 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
C7S03_RS05855 1021537..1021824 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T293208 WP_003691083.1 NZ_LT592163:c1016722-1016303 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT293208 WP_003688410.1 NZ_LT592163:c1016958-1016722 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References