Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1020028..1020683 Replicon chromosome
Accession NZ_LT592159
Organism Neisseria gonorrhoeae strain WHO_U

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag C7S04_RS05915 Protein ID WP_003691083.1
Coordinates 1020028..1020447 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag C7S04_RS05920 Protein ID WP_003688410.1
Coordinates 1020447..1020683 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7S04_RS05895 1015304..1016845 - 1542 WP_003697015.1 multidrug efflux MFS transporter -
C7S04_RS05900 1016993..1017772 + 780 WP_003688416.1 (Fe-S)-binding protein -
C7S04_RS05905 1017769..1018470 + 702 WP_003688414.1 lactate utilization protein C -
C7S04_RS05910 1018467..1019879 + 1413 WP_106333340.1 lactate utilization protein -
C7S04_RS05915 1020028..1020447 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
C7S04_RS05920 1020447..1020683 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
C7S04_RS05925 1020889..1021086 - 198 WP_033910354.1 IS3 family transposase -
C7S04_RS05930 1021131..1021709 - 579 WP_003688041.1 IS3 family transposase -
C7S04_RS05935 1021714..1022142 - 429 WP_003701165.1 helix-turn-helix domain-containing protein -
C7S04_RS05945 1022354..1022740 + 387 Protein_1024 IS110 family transposase -
C7S04_RS05950 1023123..1024013 - 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
C7S04_RS05955 1024024..1025190 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
C7S04_RS05960 1025262..1025549 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1022333..1022806 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T293205 WP_003691083.1 NZ_LT592159:c1020447-1020028 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT293205 WP_003688410.1 NZ_LT592159:c1020683-1020447 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References