Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 657255..657910 Replicon chromosome
Accession NZ_LT592146
Organism Neisseria gonorrhoeae strain WHO O

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag WHOZ_RS04110 Protein ID WP_003691083.1
Coordinates 657491..657910 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag WHOZ_RS04105 Protein ID WP_003688410.1
Coordinates 657255..657491 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WHOZ_RS04070 652389..652676 + 288 WP_025455945.1 hypothetical protein -
WHOZ_RS04075 652748..653914 + 1167 WP_047919363.1 ADP-forming succinate--CoA ligase subunit beta -
WHOZ_RS04080 653925..654815 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
WHOZ_RS04085 655198..655584 - 387 Protein_675 IS110 family transposase -
WHOZ_RS04090 655796..656224 + 429 WP_003701165.1 helix-turn-helix domain-containing protein -
WHOZ_RS04095 656229..656807 + 579 WP_003697246.1 IS3 family transposase -
WHOZ_RS04100 656804..657049 + 246 WP_003706295.1 IS3 family transposase -
WHOZ_RS04105 657255..657491 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
WHOZ_RS04110 657491..657910 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
WHOZ_RS04115 658059..659513 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
WHOZ_RS04120 659510..660211 - 702 WP_003688414.1 lactate utilization protein C -
WHOZ_RS04125 660208..660987 - 780 WP_003688416.1 (Fe-S)-binding protein -
WHOZ_RS04130 661135..662676 + 1542 WP_003697015.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 655132..655605 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T293195 WP_003691083.1 NZ_LT592146:657491-657910 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT293195 WP_003688410.1 NZ_LT592146:657255-657491 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References