Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta(toxin)
Location 11752..13403 Replicon plasmid 3
Accession NZ_LT591912
Organism Neisseria gonorrhoeae strain WHO N

Toxin (Protein)


Gene name ng_zeta1 Uniprot ID D5K9G7
Locus tag E4V86_RS12940 Protein ID WP_003701905.1
Coordinates 11752..12957 (+) Length 402 a.a.

Antitoxin (Protein)


Gene name ng_epsilon1 Uniprot ID D5K9G8
Locus tag E4V86_RS12945 Protein ID WP_003701903.1
Coordinates 12972..13403 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4V86_RS12915 8665..8781 - 117 WP_001791010.1 tetracycline resistance determinant leader peptide -
E4V86_RS12920 9169..9690 + 522 WP_003701911.1 hypothetical protein -
E4V86_RS12925 10073..10321 + 249 WP_029671738.1 hypothetical protein -
E4V86_RS12930 10318..11526 + 1209 WP_003701908.1 zeta toxin family protein -
E4V86_RS12935 11560..11745 + 186 WP_003701907.1 hypothetical protein -
E4V86_RS12940 11752..12957 + 1206 WP_003701905.1 toxin Toxin
E4V86_RS12945 12972..13403 + 432 WP_003701903.1 hypothetical protein Antitoxin
E4V86_RS12950 13455..14009 + 555 WP_003701901.1 recombinase family protein -
E4V86_RS12955 14119..14409 - 291 WP_003701899.1 virulence factor -
E4V86_RS12960 14512..15111 - 600 WP_003701898.1 TrbN protein -
E4V86_RS12965 15111..15629 - 519 WP_025456271.1 TrbM protein -
E4V86_RS12970 15676..17304 - 1629 WP_047951283.1 P-type conjugative transfer protein TrbL -
E4V86_RS12975 17518..18294 - 777 WP_003701891.1 P-type conjugative transfer protein TrbJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(M) - 1..42004 42004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

KfrB domain

(284-343)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 402 a.a.        Molecular weight: 44675.53 Da        Isoelectric Point: 7.7756

>T293194 WP_003701905.1 NZ_LT591912:11752-12957 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R

Download         Length: 1206 bp

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15927.05 Da        Isoelectric Point: 4.4211

>AT293194 WP_003701903.1 NZ_LT591912:12972-13403 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ

Download         Length: 432 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6EPI
PDB 6EPG
PDB 6EPH

Antitoxin

Source ID Structure
AlphaFold DB D5K9G8

References