Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta(toxin) |
| Location | 11752..13403 | Replicon | plasmid 3 |
| Accession | NZ_LT591912 | ||
| Organism | Neisseria gonorrhoeae strain WHO N | ||
Toxin (Protein)
| Gene name | ng_zeta1 | Uniprot ID | D5K9G7 |
| Locus tag | E4V86_RS12940 | Protein ID | WP_003701905.1 |
| Coordinates | 11752..12957 (+) | Length | 402 a.a. |
Antitoxin (Protein)
| Gene name | ng_epsilon1 | Uniprot ID | D5K9G8 |
| Locus tag | E4V86_RS12945 | Protein ID | WP_003701903.1 |
| Coordinates | 12972..13403 (+) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E4V86_RS12915 | 8665..8781 | - | 117 | WP_001791010.1 | tetracycline resistance determinant leader peptide | - |
| E4V86_RS12920 | 9169..9690 | + | 522 | WP_003701911.1 | hypothetical protein | - |
| E4V86_RS12925 | 10073..10321 | + | 249 | WP_029671738.1 | hypothetical protein | - |
| E4V86_RS12930 | 10318..11526 | + | 1209 | WP_003701908.1 | zeta toxin family protein | - |
| E4V86_RS12935 | 11560..11745 | + | 186 | WP_003701907.1 | hypothetical protein | - |
| E4V86_RS12940 | 11752..12957 | + | 1206 | WP_003701905.1 | toxin | Toxin |
| E4V86_RS12945 | 12972..13403 | + | 432 | WP_003701903.1 | hypothetical protein | Antitoxin |
| E4V86_RS12950 | 13455..14009 | + | 555 | WP_003701901.1 | recombinase family protein | - |
| E4V86_RS12955 | 14119..14409 | - | 291 | WP_003701899.1 | virulence factor | - |
| E4V86_RS12960 | 14512..15111 | - | 600 | WP_003701898.1 | TrbN protein | - |
| E4V86_RS12965 | 15111..15629 | - | 519 | WP_025456271.1 | TrbM protein | - |
| E4V86_RS12970 | 15676..17304 | - | 1629 | WP_047951283.1 | P-type conjugative transfer protein TrbL | - |
| E4V86_RS12975 | 17518..18294 | - | 777 | WP_003701891.1 | P-type conjugative transfer protein TrbJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(M) | - | 1..42004 | 42004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 402 a.a. Molecular weight: 44675.53 Da Isoelectric Point: 7.7756
>T293194 WP_003701905.1 NZ_LT591912:11752-12957 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
Download Length: 1206 bp
Antitoxin
Download Length: 144 a.a. Molecular weight: 15927.05 Da Isoelectric Point: 4.4211
>AT293194 WP_003701903.1 NZ_LT591912:12972-13403 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
Download Length: 432 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|