Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 727948..728603 Replicon chromosome
Accession NZ_LT591910
Organism Neisseria gonorrhoeae strain WHO N

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag E4V86_RS04430 Protein ID WP_003691083.1
Coordinates 728184..728603 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag E4V86_RS04425 Protein ID WP_003688410.1
Coordinates 727948..728184 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4V86_RS04390 723082..723369 + 288 WP_003688407.1 hypothetical protein -
E4V86_RS04395 723441..724607 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
E4V86_RS04400 724618..725508 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
E4V86_RS04405 725891..726277 - 387 Protein_754 IS110 family transposase -
E4V86_RS04410 726489..726917 + 429 WP_003701165.1 helix-turn-helix domain-containing protein -
E4V86_RS04415 726922..727500 + 579 WP_003688041.1 IS3 family transposase -
E4V86_RS04420 727497..727742 + 246 WP_003706295.1 IS3 family transposase -
E4V86_RS04425 727948..728184 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
E4V86_RS04430 728184..728603 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
E4V86_RS04435 728752..730206 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
E4V86_RS04440 730203..730904 - 702 WP_003688414.1 lactate utilization protein C -
E4V86_RS04445 730901..731680 - 780 WP_003688416.1 (Fe-S)-binding protein -
E4V86_RS04450 731828..733369 + 1542 WP_003693283.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T293192 WP_003691083.1 NZ_LT591910:728184-728603 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT293192 WP_003688410.1 NZ_LT591910:727948-728184 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References