Detailed information of TA system TA029319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 196087..196585
• Replicon: draft genome
• Accession: NC_021006
• Organism: Streptococcus pneumoniae SPN034156

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SPN034156_RS00955
• Protein ID: WP_001812387.1
• Coordinates: 196087..196341 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: SPN034156_RS00960
• Protein ID: WP_000208080.1
• Coordinates: 196343..196585 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPN034156_RS00940	191348..193816	-	2469	WP_001152997.1	DNA gyrase subunit A	-
SPN034156_RS00945	194010..194996	+	987	WP_000204733.1	L-lactate dehydrogenase	-
SPN034156_RS00950	195345..196040	-	696	WP_000731127.1	potassium channel family protein	-
SPN034156_RS00955	196087..196341	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPN034156_RS00960	196343..196585	-	243	WP_000208080.1	hypothetical protein	Antitoxin
SPN034156_RS00965	196676..197485	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
SPN034156_RS00970	197487..198836	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
SPN034156_RS00975	198829..199533	-	705	WP_000722076.1	response regulator transcription factor	-
SPN034156_RS00980	199588..200763	-	1176	WP_000886147.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T29319 WP_001812387.1 NC_021006:c196341-196087 [Streptococcus pneumoniae SPN034156]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T29319 NC_021006:c196341-196087 [Streptococcus pneumoniae SPN034156]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT29319 WP_000208080.1 NC_021006:c196585-196343 [Streptococcus pneumoniae SPN034156]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT29319 NC_021006:c196585-196343 [Streptococcus pneumoniae SPN034156]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7