Detailed information of TA system TA293187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta(toxin)
• Location: 8802..10453
• Replicon: plasmid 2
• Accession: NZ_LT591902
• Organism: Neisseria gonorrhoeae strain WHO L

Toxin (Protein)

• Gene name: ng_zeta1
• Uniprot ID: -
• Locus tag: C7S00_RS12890
• Protein ID: WP_033911112.1
• Coordinates: 8802..10007 (+)
• Length: 402 a.a.

Antitoxin (Protein)

• Gene name: ng_epsilon1
• Uniprot ID: D5K9G8
• Locus tag: C7S00_RS12895
• Protein ID: WP_003701903.1
• Coordinates: 10022..10453 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7S00_RS12855	4390..4758	+	369	WP_003701920.1	hypothetical protein	-
C7S00_RS12860	4742..5113	+	372	WP_003701919.1	hypothetical protein	-
C7S00_RS12865	5117..6013	+	897	WP_003701917.1	hypothetical protein	-
C7S00_RS12870	6165..6653	-	489	WP_014580055.1	hypothetical protein	-
C7S00_RS12875	7123..7371	+	249	WP_014580056.1	hypothetical protein	-
C7S00_RS12880	7368..8576	+	1209	WP_014580057.1	zeta toxin family protein	-
C7S00_RS12885	8610..8795	+	186	WP_014580058.1	hypothetical protein	-
C7S00_RS12890	8802..10007	+	1206	WP_033911112.1	zeta toxin family protein	Toxin
C7S00_RS12895	10022..10453	+	432	WP_003701903.1	hypothetical protein	Antitoxin
C7S00_RS12900	10505..11059	+	555	WP_003701901.1	recombinase family protein	-
C7S00_RS12905	11169..11459	-	291	WP_003701899.1	virulence factor	-
C7S00_RS12910	11562..12161	-	600	WP_003701898.1	TrbN protein	-
C7S00_RS12915	12161..12739	-	579	WP_033911116.1	TrbM protein	-
C7S00_RS12920	12726..14354	-	1629	WP_047920931.1	P-type conjugative transfer protein TrbL	-
C7S00_RS12925	14568..15344	-	777	WP_003701891.1	P-type conjugative transfer protein TrbJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..39054	39054

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• KfrB domain (284-343)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 402 a.a.
• Molecular weight: 44747.59 Da
• Isoelectric Point: 7.2930

>T293187 WP_033911112.1 NZ_LT591902:8802-10007 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGREASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R

Nucleotide

• Length: 1206 bp

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15927.05 Da
• Isoelectric Point: 4.4211

>AT293187 WP_003701903.1 NZ_LT591902:10022-10453 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ

Nucleotide

• Length: 432 bp

Structures

Antitoxin

• AlphaFold DB: D5K9G8