293185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1116881..1117536 Replicon chromosome
Accession NZ_LT591901
Organism Neisseria gonorrhoeae strain WHO L

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag C7S00_RS06380 Protein ID WP_003691083.1
Coordinates 1116881..1117300 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag C7S00_RS06385 Protein ID WP_003688410.1
Coordinates 1117300..1117536 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7S00_RS06360 1112115..1113656 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
C7S00_RS06365 1113804..1114583 + 780 WP_003688416.1 (Fe-S)-binding protein -
C7S00_RS06370 1114580..1115281 + 702 WP_003688414.1 lactate utilization protein C -
C7S00_RS06375 1115278..1116732 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
C7S00_RS06380 1116881..1117300 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
C7S00_RS06385 1117300..1117536 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
C7S00_RS06390 1117742..1117939 - 198 WP_033910354.1 IS3 family transposase -
C7S00_RS06395 1117984..1118562 - 579 WP_003688041.1 IS3 family transposase -
C7S00_RS06400 1118567..1118995 - 429 WP_010360042.1 helix-turn-helix domain-containing protein -
C7S00_RS06405 1119207..1119593 + 387 Protein_1107 IS110 family transposase -
C7S00_RS06410 1119976..1120866 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
C7S00_RS06415 1120877..1122043 - 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
C7S00_RS06420 1122115..1122402 - 288 WP_025455945.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T293185 WP_003691083.1 NZ_LT591901:c1117300-1116881 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT293185 WP_003688410.1 NZ_LT591901:c1117536-1117300 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
AlphaFold DB Q5F881

References