Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 943399..944866 Replicon chromosome
Accession NZ_LT578453
Organism Mycoplasma bovis isolate JF4278

Toxin (Protein)


Gene name abiEi Uniprot ID A0A2N8U3K6
Locus tag MBOVJF4428_RS04030 Protein ID WP_014829995.1
Coordinates 943399..944259 (-) Length 287 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID Q934C3
Locus tag MBOVJF4428_RS04035 Protein ID WP_013456322.1
Coordinates 944252..944866 (-) Length 205 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBOVJF4428_RS04010 939432..940040 + 609 WP_157823756.1 variable surface lipoprotein -
MBOVJF4428_RS04015 940370..941386 - 1017 WP_013455927.1 IS30 family transposase -
MBOVJF4428_RS04565 941693..942187 + 495 Protein_767 collagen-like protein -
MBOVJF4428_RS04635 942190..942297 - 108 Protein_768 variable surface lipoprotein -
MBOVJF4428_RS04025 942464..943279 - 816 Protein_769 variable surface lipoprotein -
MBOVJF4428_RS04030 943399..944259 - 861 WP_014829995.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MBOVJF4428_RS04035 944252..944866 - 615 WP_013456322.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
MBOVJF4428_RS04605 945049..945156 + 108 Protein_772 variable surface lipoprotein -
MBOVJF4428_RS04045 946166..947599 + 1434 WP_101456648.1 transposase -
MBOVJF4428_RS04050 947938..948267 - 330 Protein_774 variable surface lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 917937..954676 36739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-234)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(13-59)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 33280.36 Da        Isoelectric Point: 7.7731

>T293176 WP_014829995.1 NZ_LT578453:c944259-943399 [Mycoplasma bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Download         Length: 861 bp

Antitoxin


Download         Length: 205 a.a.        Molecular weight: 24143.83 Da        Isoelectric Point: 9.7617

>AT293176 WP_013456322.1 NZ_LT578453:c944866-944252 [Mycoplasma bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Download         Length: 615 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8U3K6

Antitoxin

Source ID Structure
AlphaFold DB Q934C3

References