Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1572357..1573025 Replicon draft genome
Accession NC_021005
Organism Streptococcus pneumoniae SPN994039

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag SPN994039_RS08365 Protein ID WP_001132285.1
Coordinates 1572846..1573025 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4J1XUY0
Locus tag SPN994039_RS08360 Protein ID WP_000961812.1
Coordinates 1572357..1572809 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPN994039_RS08335 1568247..1568990 - 744 WP_001188204.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SPN994039_RS08340 1568992..1569942 - 951 WP_000451160.1 50S ribosomal protein L11 methyltransferase -
SPN994039_RS08345 1570080..1570508 - 429 WP_000418157.1 NUDIX hydrolase -
SPN994039_RS08350 1570489..1571577 - 1089 WP_000719712.1 M50 family metallopeptidase -
SPN994039_RS08355 1571596..1572066 - 471 WP_000257088.1 DUF3013 family protein -
SPN994039_RS08360 1572357..1572809 - 453 WP_000961812.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPN994039_RS08365 1572846..1573025 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
SPN994039_RS08370 1573162..1573410 - 249 WP_000797237.1 hypothetical protein -
SPN994039_RS08375 1573400..1573639 - 240 WP_000818079.1 hypothetical protein -
SPN994039_RS08380 1573909..1575180 + 1272 WP_001113213.1 replication-associated recombination protein A -
SPN994039_RS08390 1575600..1576727 - 1128 WP_000323403.1 site-specific integrase -
SPN994039_RS08395 1576729..1576911 - 183 WP_000655518.1 DUF3173 domain-containing protein -
SPN994039_RS08400 1576927..1577970 - 1044 WP_001031659.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T29317 WP_001132285.1 NC_021005:c1573025-1572846 [Streptococcus pneumoniae SPN994039]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T29317 NC_021005:c1573025-1572846 [Streptococcus pneumoniae SPN994039]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT29317 WP_000961812.1 NC_021005:c1572809-1572357 [Streptococcus pneumoniae SPN994039]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGLTVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT29317 NC_021005:c1572809-1572357 [Streptococcus pneumoniae SPN994039]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGCTAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A4J1XUY0

References