Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3388384..3389957 Replicon chromosome
Accession NZ_LT575468
Organism Plesiomonas shigelloides strain NCTC10360

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NCTC9997_RS15050 Protein ID WP_064978374.1
Coordinates 3388384..3389703 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NCTC9997_RS15055 Protein ID WP_017410478.1
Coordinates 3389703..3389957 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC9997_RS15040 3384925..3385371 - 447 WP_064978372.1 FMN-binding protein MioC -
NCTC9997_RS15045 3385859..3387910 + 2052 WP_064978373.1 PTS sugar transporter subunit IIC/EAL domain-containing protein -
NCTC9997_RS15050 3388384..3389703 - 1320 WP_064978374.1 type II toxin-antitoxin system HipA family toxin Toxin
NCTC9997_RS15055 3389703..3389957 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
NCTC9997_RS15060 3390496..3391113 + 618 WP_064978536.1 recombinase family protein -
NCTC9997_RS15065 3391110..3391433 - 324 WP_064978375.1 hypothetical protein -
NCTC9997_RS15070 3392123..3392859 - 737 Protein_2869 IS5 family transposase -
NCTC9997_RS15080 3393338..3394300 + 963 WP_064978379.1 site-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49560.63 Da        Isoelectric Point: 6.8253

>T293167 WP_064978374.1 NZ_LT575468:c3389703-3388384 [Plesiomonas shigelloides]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYIDGRWYLPLKATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLACSKGKKYSIEQIFPRHFFQTAKTVGFERSAMEEILTELANSV
DNVIELVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT293167 WP_017410478.1 NZ_LT575468:c3389957-3389703 [Plesiomonas shigelloides]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References