Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1619416..1620185 Replicon chromosome
Accession NZ_LT575468
Organism Plesiomonas shigelloides strain NCTC10360

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NCTC9997_RS07025 Protein ID WP_064977675.1
Coordinates 1619416..1619913 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A379CP68
Locus tag NCTC9997_RS07030 Protein ID WP_064977676.1
Coordinates 1619913..1620185 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC9997_RS07005 1614502..1614936 - 435 WP_167550129.1 phosphate-starvation-inducible PsiE family protein -
NCTC9997_RS07010 1615342..1615899 + 558 WP_152135787.1 hypothetical protein -
NCTC9997_RS07015 1616178..1616603 - 426 WP_064977674.1 GNAT family N-acetyltransferase -
NCTC9997_RS15225 1617446..1618024 - 579 WP_197665254.1 hypothetical protein -
NCTC9997_RS15230 1618008..1618466 - 459 WP_197665255.1 hypothetical protein -
NCTC9997_RS07025 1619416..1619913 - 498 WP_064977675.1 GNAT family N-acetyltransferase Toxin
NCTC9997_RS07030 1619913..1620185 - 273 WP_064977676.1 DUF1778 domain-containing protein Antitoxin
NCTC9997_RS07035 1620485..1620895 + 411 WP_064977677.1 glyoxalase -
NCTC9997_RS07040 1621646..1621834 + 189 WP_156669252.1 hypothetical protein -
NCTC9997_RS07045 1622323..1622574 - 252 WP_064977679.1 hypothetical protein -
NCTC9997_RS07050 1622999..1623502 - 504 WP_082935587.1 hypothetical protein -
NCTC9997_RS07055 1623607..1624314 - 708 WP_064977681.1 hypothetical protein -
NCTC9997_RS07060 1624409..1624696 + 288 WP_064977682.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1551411..1630373 78962


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18590.30 Da        Isoelectric Point: 7.3555

>T293166 WP_064977675.1 NZ_LT575468:c1619913-1619416 [Plesiomonas shigelloides]
METVLLDKSKHERHHFDCGVDALNNYLKVMASQQAKRDNSRTFVLEDDNDPRIIVGFYTLTMTPIDLKALPPQLQKKHQS
STSGGLIARLAIDKRYKGKGIGEWLLIDALKKLLQASNTVAFPVIIVDAKDGAENFYTKYGFTPFTETDNKLFITIADIR
SSLDE

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9783.38 Da        Isoelectric Point: 10.0958

>AT293166 WP_064977676.1 NZ_LT575468:c1620185-1619913 [Plesiomonas shigelloides]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQILEREQALKLSQRDAMLLVEALDQPAKSNDKLKA
AAARYKDKTL

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A379CP68

References