293165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1945362..1945871 Replicon chromosome
Accession NZ_LT571449
Organism Staphylococcus epidermidis isolate BPH0662

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag BN6763_RS09960 Protein ID WP_001829980.1
Coordinates 1945362..1945571 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag BN6763_RS09965 Protein ID WP_001829893.1
Coordinates 1945578..1945871 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN6763_RS09940 1940940..1942295 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
BN6763_RS09945 1942307..1943380 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
BN6763_RS09950 1943771..1944982 + 1212 WP_001829910.1 rod shape-determining protein RodA -
BN6763_RS09955 1945082..1945219 - 138 WP_001829949.1 hypothetical protein -
BN6763_RS09960 1945362..1945571 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
BN6763_RS09965 1945578..1945871 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
BN6763_RS09970 1946045..1947529 + 1485 WP_002504877.1 cardiolipin synthase -
BN6763_RS09975 1947711..1948364 + 654 WP_001829983.1 HD domain-containing protein -
BN6763_RS09980 1948470..1949342 - 873 WP_002458703.1 membrane protein insertase YidC -
BN6763_RS09985 1949431..1950069 - 639 WP_002505076.1 thiamine phosphate synthase -
BN6763_RS09990 1950075..1950863 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T293165 WP_001829980.1 NZ_LT571449:c1945571-1945362 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T293165 NZ_LT571449:c1945571-1945362 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT293165 WP_001829893.1 NZ_LT571449:c1945871-1945578 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT293165 NZ_LT571449:c1945871-1945578 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References