Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1851821..1852449 Replicon chromosome
Accession NZ_LT571436
Organism Neisseria weaveri strain NCTC13585

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A8Q77_RS08640 Protein ID WP_064130873.1
Coordinates 1852048..1852449 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3S4ZDA2
Locus tag A8Q77_RS08635 Protein ID WP_004284447.1
Coordinates 1851821..1852045 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8Q77_RS08610 1847307..1847771 - 465 WP_004284441.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
A8Q77_RS10710 1847837..1848550 - 714 WP_172795948.1 ComF family protein -
A8Q77_RS08620 1848549..1849292 + 744 WP_004284444.1 pimeloyl-ACP methyl ester esterase BioH -
A8Q77_RS08625 1849368..1850156 + 789 WP_004284445.1 methyltransferase domain-containing protein -
A8Q77_RS08630 1850308..1851675 + 1368 WP_064130872.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
A8Q77_RS08635 1851821..1852045 + 225 WP_004284447.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A8Q77_RS08640 1852048..1852449 + 402 WP_064130873.1 tRNA(fMet)-specific endonuclease VapC Toxin
A8Q77_RS08645 1852808..1853977 + 1170 WP_064130874.1 benzoate/H(+) symporter BenE family transporter -
A8Q77_RS08650 1854228..1855649 + 1422 WP_004284450.1 alanine:cation symporter family protein -
A8Q77_RS08655 1855751..1856551 - 801 WP_004284451.1 cytochrome c biogenesis protein CcsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-35)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14841.11 Da        Isoelectric Point: 7.9466

>T293160 WP_064130873.1 NZ_LT571436:1852048-1852449 [Neisseria weaveri]
MLRYMLDTNICIYTIKNNPAAVREKFQQHQHHMCISSIVLTELLYGAEKSSNPAKSLALVEGMAARLEVLNFDETAAAHA
AEIRADLTRKGTPIGHYDVLIAGHARSRGLILVSNNLREFERVAGLRLENWAV

Download         Length: 402 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8436.55 Da        Isoelectric Point: 4.6721

>AT293160 WP_004284447.1 NZ_LT571436:1851821-1852045 [Neisseria weaveri]
MAQATLFKSNQTQAVRLPKAVAFPDDVKKVEVVVLGKSRLLTPSENLWDDWFAQLPQADFPDREPSFQAERESF

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4ZDA2

References