293149

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1026301..1026926 Replicon chromosome
Accession NZ_LT556085
Organism Citrobacter amalonaticus strain 92

Toxin (Protein)


Gene name vapC Uniprot ID A0A381GI10
Locus tag CITRO92_RS05050 Protein ID WP_042998865.1
Coordinates 1026301..1026687 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CITRO92_RS05055 Protein ID WP_162300700.1
Coordinates 1026687..1026926 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CITRO92_RS05030 1021654..1022991 + 1338 WP_086512772.1 VWA domain-containing protein -
CITRO92_RS05035 1023009..1024505 + 1497 WP_109739661.1 HAMP domain-containing histidine kinase -
CITRO92_RS05040 1024510..1025196 + 687 WP_044257174.1 response regulator transcription factor -
CITRO92_RS05045 1025341..1026270 + 930 WP_042998866.1 formate dehydrogenase accessory protein FdhE -
CITRO92_RS05050 1026301..1026687 - 387 WP_042998865.1 type II toxin-antitoxin system VapC family toxin Toxin
CITRO92_RS05055 1026687..1026926 - 240 WP_162300700.1 ribbon-helix-helix domain-containing protein Antitoxin
CITRO92_RS05060 1027136..1028062 + 927 WP_061069448.1 alpha/beta hydrolase -
CITRO92_RS05065 1028078..1029019 - 942 WP_042998862.1 fatty acid biosynthesis protein FabY -
CITRO92_RS05070 1029064..1029501 - 438 WP_044265155.1 D-tyrosyl-tRNA(Tyr) deacylase -
CITRO92_RS05075 1029498..1030370 - 873 WP_044257165.1 virulence factor BrkB family protein -
CITRO92_RS05080 1030364..1030963 - 600 WP_044265152.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-46)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14404.65 Da        Isoelectric Point: 9.4114

>T293149 WP_042998865.1 NZ_LT556085:c1026687-1026301 [Citrobacter amalonaticus]
MQKGPVLFDTNILIDLFSGRQEAQQVLEAYPPQNAISLVTWMEVMVGAKKYHQEYRTRVALSAFNIIGVSQEIAERSVNL
RQEYGMKLPDAIILATAQIHRFALVTRNTRDFAGIPGVITPYQLQAGR

Download         Length: 387 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9254.43 Da        Isoelectric Point: 4.2075

>AT293149 WP_162300700.1 NZ_LT556085:c1026926-1026687 [Citrobacter amalonaticus]
MAGMDMGRILLDLSDEMIKRLDDLKQQRNLPRAELLREAVEQYLERQGQAETTISNALGLWQGCEEDGVEYQRTLREEW

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A381GI10

Antitoxin

Source ID Structure

References