Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4195076..4195696 Replicon chromosome
Accession NZ_LT556084
Organism Citrobacter amalonaticus strain 86

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CITRO86_RS20805 Protein ID WP_001280991.1
Coordinates 4195478..4195696 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q8DH98
Locus tag CITRO86_RS20800 Protein ID WP_042324455.1
Coordinates 4195076..4195450 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CITRO86_RS20790 4190200..4191393 + 1194 WP_043001556.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CITRO86_RS20795 4191416..4194565 + 3150 WP_043001557.1 multidrug efflux RND transporter permease subunit -
CITRO86_RS20800 4195076..4195450 + 375 WP_042324455.1 Hha toxicity modulator TomB Antitoxin
CITRO86_RS20805 4195478..4195696 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
CITRO86_RS20810 4195873..4196424 + 552 WP_044258934.1 maltose O-acetyltransferase -
CITRO86_RS20815 4196538..4197008 + 471 WP_043001559.1 YlaC family protein -
CITRO86_RS20820 4197058..4197198 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CITRO86_RS20825 4197421..4198971 + 1551 WP_109739954.1 EAL domain-containing protein -
CITRO86_RS20830 4199011..4199364 - 354 WP_043001561.1 DUF1428 family protein -
CITRO86_RS20835 4199447..4200043 - 597 WP_044258943.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T293142 WP_001280991.1 NZ_LT556084:4195478-4195696 [Citrobacter amalonaticus]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8989

>AT293142 WP_042324455.1 NZ_LT556084:4195076-4195450 [Citrobacter amalonaticus]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DH98

References