Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 700959..701627 Replicon draft genome
Accession NC_021003
Organism Streptococcus pneumoniae SPN032672

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SPN032672_RS03670 Protein ID WP_001132276.1
Coordinates 701448..701627 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag SPN032672_RS03665 Protein ID WP_000961810.1
Coordinates 700959..701411 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPN032672_RS03640 696849..697592 - 744 WP_001188229.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SPN032672_RS03645 697594..698544 - 951 WP_000451130.1 50S ribosomal protein L11 methyltransferase -
SPN032672_RS03650 698682..699110 - 429 WP_000418168.1 NUDIX hydrolase -
SPN032672_RS03655 699091..700179 - 1089 WP_000719722.1 M50 family metallopeptidase -
SPN032672_RS03660 700198..700668 - 471 WP_000257107.1 DUF3013 family protein -
SPN032672_RS03665 700959..701411 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPN032672_RS03670 701448..701627 - 180 WP_001132276.1 type II toxin-antitoxin system HicA family toxin Toxin
SPN032672_RS03675 701764..701943 - 180 WP_001809903.1 hypothetical protein -
SPN032672_RS03680 702108..702326 - 219 WP_001273377.1 hypothetical protein -
SPN032672_RS03685 702319..703267 - 949 Protein_712 IS30 family transposase -
SPN032672_RS03690 703858..705129 + 1272 WP_001113209.1 replication-associated recombination protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6630.80 Da        Isoelectric Point: 10.8214

>T29314 WP_001132276.1 NC_021003:c701627-701448 [Streptococcus pneumoniae SPN032672]
MPMTQKEMVKLFTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 180 bp

>T29314 NC_021003:c701627-701448 [Streptococcus pneumoniae SPN032672]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCTTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT29314 WP_000961810.1 NC_021003:c701411-700959 [Streptococcus pneumoniae SPN032672]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT29314 NC_021003:c701411-700959 [Streptococcus pneumoniae SPN032672]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References