Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1468038..1468692 Replicon chromosome
Accession NZ_LT556084
Organism Citrobacter amalonaticus strain 86

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag CITRO86_RS07245 Protein ID WP_044254016.1
Coordinates 1468285..1468692 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag CITRO86_RS07240 Protein ID WP_042322123.1
Coordinates 1468038..1468304 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CITRO86_RS07210 1463606..1464100 - 495 Protein_1336 MurR/RpiR family transcriptional regulator -
CITRO86_RS07215 1464171..1465151 + 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
CITRO86_RS07220 1465283..1465534 - 252 Protein_1338 MurR/RpiR family transcriptional regulator -
CITRO86_RS07225 1465587..1465898 + 312 WP_109739478.1 N(4)-acetylcytidine aminohydrolase -
CITRO86_RS07230 1466061..1466720 + 660 WP_044264418.1 hemolysin III family protein -
CITRO86_RS07235 1466801..1467781 - 981 WP_109739477.1 tRNA-modifying protein YgfZ -
CITRO86_RS07240 1468038..1468304 + 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
CITRO86_RS07245 1468285..1468692 + 408 WP_044254016.1 protein YgfX Toxin
CITRO86_RS07250 1468793..1469314 - 522 WP_042999366.1 flavodoxin FldB -
CITRO86_RS07255 1469415..1470311 + 897 WP_042999367.1 site-specific tyrosine recombinase XerD -
CITRO86_RS07260 1470335..1471048 + 714 WP_042999368.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CITRO86_RS07265 1471054..1472787 + 1734 WP_042999369.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1464171..1465151 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T293135 WP_044254016.1 NZ_LT556084:1468285-1468692 [Citrobacter amalonaticus]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT293135 WP_042322123.1 NZ_LT556084:1468038-1468304 [Citrobacter amalonaticus]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References