Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1351150..1351829 Replicon chromosome
Accession NZ_LT556084
Organism Citrobacter amalonaticus strain 86

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag CITRO86_RS06625 Protein ID WP_109739503.1
Coordinates 1351488..1351829 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag CITRO86_RS06620 Protein ID WP_109739504.1
Coordinates 1351150..1351467 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CITRO86_RS06580 1346425..1347246 + 822 WP_109739512.1 DUF945 domain-containing protein -
CITRO86_RS06585 1347463..1348164 + 702 WP_109739511.1 WYL domain-containing protein -
CITRO86_RS06590 1348203..1349042 + 840 WP_109739510.1 hypothetical protein -
CITRO86_RS06595 1349064..1349537 + 474 WP_109739509.1 hypothetical protein -
CITRO86_RS06600 1349615..1349854 + 240 WP_109739508.1 DUF905 domain-containing protein -
CITRO86_RS06605 1349951..1350409 + 459 WP_109739507.1 antirestriction protein -
CITRO86_RS06610 1350425..1350901 + 477 WP_109739506.1 RadC family protein -
CITRO86_RS06615 1350910..1351131 + 222 WP_109739505.1 DUF987 domain-containing protein -
CITRO86_RS06620 1351150..1351467 + 318 WP_109739504.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CITRO86_RS06625 1351488..1351829 + 342 WP_109739503.1 TA system toxin CbtA family protein Toxin
CITRO86_RS06630 1351945..1352778 + 834 WP_109739502.1 DUF4942 domain-containing protein -
CITRO86_RS06635 1353011..1353808 + 798 WP_109739501.1 helix-turn-helix transcriptional regulator -
CITRO86_RS06645 1354128..1354874 - 747 WP_109739500.1 epimerase -
CITRO86_RS06650 1354885..1355175 - 291 WP_044264508.1 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase -
CITRO86_RS06655 1355224..1356099 - 876 WP_000774153.1 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1334989..1353808 18819


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12885.04 Da        Isoelectric Point: 9.9572

>T293134 WP_109739503.1 NZ_LT556084:1351488-1351829 [Citrobacter amalonaticus]
MKILPATISRAAKPCLPPVAVWQMLLTRLLEKHYGLTLNDTPFSDEIVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11796.40 Da        Isoelectric Point: 6.9367

>AT293134 WP_109739504.1 NZ_LT556084:1351150-1351467 [Citrobacter amalonaticus]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISQIESMLTTYELNPRHAHCVTLCH
NGFTCEADTLGSCGYVYVAVYSTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References