Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 822685..823310 Replicon chromosome
Accession NZ_LT556084
Organism Citrobacter amalonaticus strain 86

Toxin (Protein)


Gene name vapC Uniprot ID A0A381GI10
Locus tag CITRO86_RS04085 Protein ID WP_042998865.1
Coordinates 822924..823310 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CITRO86_RS04080 Protein ID WP_162300700.1
Coordinates 822685..822924 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CITRO86_RS04055 818648..819247 + 600 WP_044265152.1 glucose-1-phosphatase -
CITRO86_RS04060 819241..820113 + 873 WP_044257165.1 virulence factor BrkB family protein -
CITRO86_RS04065 820110..820547 + 438 WP_044265155.1 D-tyrosyl-tRNA(Tyr) deacylase -
CITRO86_RS04070 820592..821533 + 942 WP_042998862.1 fatty acid biosynthesis protein FabY -
CITRO86_RS04075 821549..822475 - 927 WP_061069448.1 alpha/beta hydrolase -
CITRO86_RS04080 822685..822924 + 240 WP_162300700.1 ribbon-helix-helix domain-containing protein Antitoxin
CITRO86_RS04085 822924..823310 + 387 WP_042998865.1 type II toxin-antitoxin system VapC family toxin Toxin
CITRO86_RS04090 823341..824270 - 930 WP_042998866.1 formate dehydrogenase accessory protein FdhE -
CITRO86_RS04095 824415..825101 - 687 WP_044257174.1 response regulator transcription factor -
CITRO86_RS04100 825106..826602 - 1497 WP_109739661.1 HAMP domain-containing histidine kinase -
CITRO86_RS04105 826620..827957 - 1338 WP_086512772.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-46)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14404.65 Da        Isoelectric Point: 9.4114

>T293132 WP_042998865.1 NZ_LT556084:822924-823310 [Citrobacter amalonaticus]
MQKGPVLFDTNILIDLFSGRQEAQQVLEAYPPQNAISLVTWMEVMVGAKKYHQEYRTRVALSAFNIIGVSQEIAERSVNL
RQEYGMKLPDAIILATAQIHRFALVTRNTRDFAGIPGVITPYQLQAGR

Download         Length: 387 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9254.43 Da        Isoelectric Point: 4.2075

>AT293132 WP_162300700.1 NZ_LT556084:822685-822924 [Citrobacter amalonaticus]
MAGMDMGRILLDLSDEMIKRLDDLKQQRNLPRAELLREAVEQYLERQGQAETTISNALGLWQGCEEDGVEYQRTLREEW

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A381GI10

Antitoxin

Source ID Structure

References