Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 185999..186497 Replicon draft genome
Accession NC_021003
Organism Streptococcus pneumoniae SPN032672

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag SPN032672_RS00935 Protein ID WP_001809704.1
Coordinates 185999..186253 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag SPN032672_RS00940 Protein ID WP_000208080.1
Coordinates 186255..186497 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPN032672_RS00920 181271..183739 - 2469 WP_001152988.1 DNA gyrase subunit A -
SPN032672_RS00925 183933..184919 + 987 WP_000204724.1 L-lactate dehydrogenase -
SPN032672_RS00930 185179..185952 - 774 WP_000731131.1 ion transporter -
SPN032672_RS00935 185999..186253 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPN032672_RS00940 186255..186497 - 243 WP_000208080.1 hypothetical protein Antitoxin
SPN032672_RS00945 186588..187397 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
SPN032672_RS00950 187399..188748 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
SPN032672_RS00955 188741..189445 - 705 WP_000722076.1 response regulator transcription factor -
SPN032672_RS00960 189500..190675 - 1176 WP_000886148.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T29313 WP_001809704.1 NC_021003:c186253-185999 [Streptococcus pneumoniae SPN032672]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T29313 NC_021003:c186253-185999 [Streptococcus pneumoniae SPN032672]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGATCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT29313 WP_000208080.1 NC_021003:c186497-186255 [Streptococcus pneumoniae SPN032672]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT29313 NC_021003:c186497-186255 [Streptococcus pneumoniae SPN032672]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References